NYHA Class III-IV
LVOT gradient >50 mmHg at rest or provocation
Septal thickness 15-30mm at the site of obstruction
SAM on the mitral valve
Favourable coronary anatomy
Recurrent exertional syncope
Advanced age
Absence of pathology that requires surgical correction
Symptoms despite maximal drug therapy
Patients aversion to surgery
High surgical risk due to co-morbidities