The Physicochemical Properties of Liposome
The obtained amounts for EE, particles size and z- potential was 51.34, 419 nm and -57 mV, respectively (without any data). It should be noted, in this research, did not use of any method for particle size reduction (e.g. sonication, homogenization or extrusion). This matter caused to reduce executive stages, as well as to be economic. Also, these methods because of using of high stress and pressure, can destroy the membrane of liposome. The required energy to produce small liposomal particles supplied by magnet stirrer with agitation speed 1000 rpm along with thermal treatment. Also, to prepare liposomes by Mozafari method, did not use any organic solvents or detergent. Because these solvents can cause production toxicity. In addition to, solvent remove processes are time-consuming and costly (Jahanfar et al., 2020)