Conclusion
In this study, we studied the effect of the permutation of three M2e
peptides derived from human, swine and avian IAV on the surface of PCV2
VLPs on the immune effect of IAV universal vaccine. Results demonstrate
that the M2e peptide closest to the surface of the nanoparticle induced
the highest immune protection against this species of IAV. This result
suggests that the M2e of IAV of a specific host should be stably
displayed when designing universal nanovaccines.