References
Al-Tawfiq, J. A., Al-Homoud, A. H. and
Memish, Z. A. (2020) Remdesivir as a possible therapeutic option for the
COVID-19. Travel medicine and infectious disease , 101615-101615.
Ali, S., Mustafa, S., Metzger, W. J.
A. and actions (1992) Adenosine-induced bronchoconstriction in an
allergic rabbit model: antagonism by theophylline aerosol. 37 (3-4),
165-167.
Almario, B., Wu, S., Peng, J.,
Alapati, D., Chen, S. and Sosenko, I. R. (2012) Pentoxifylline and
prevention of hyperoxia-induced lung injury in neonatal rats.Pediatric research 71 (5), 583-589.
Amvros’ eva, T., Votiakov, V.,
Andreeva, O., Vladyko, G., Nikolaeva, S., Orlova, S., Azarova, I. and
Zgirovskaia, A. (1993) New properties of trental as an inhibitor of
viral activity with a wide range of activity. Voprosy virusologii38 (5), 230-233.
Batista, M. N., Carneiro, B. M.,
Braga, A. C. S. and Rahal, P. J. A. o. v. (2015) Caffeine inhibits
hepatitis C virus replication in vitro. 160 (2), 399-407.
Batterman, R., Grossman, A., Dubinsky,
J., Mouratoff, G. J. I. r. o. m. and clinics, g. p. (1959) Reevaluation
of the usefulness of theobromine calcium gluconate for the management of
congestive heart failure and anginal syndrome. 172 (6), 318.
Bauer, T. T., Ewig, S., Rodloff, A. C.
and Müller, E. E. (2006) Acute respiratory distress syndrome and
pneumonia: a comprehensive review of clinical data. Clinical
Infectious Diseases 43 (6), 748-756.
Becker, A. B., Simons, K. J.,
Gillespie, C. A. and Simons, F. E. R. (1984) The Bronchodilator Effects
and Pharmacokinetics of Caffeine in Asthma. 310 (12), 743-746.
Bishop, N. C., Fitzgerald, C., Porter,
P. J., Scanlon, G. A. and Smith, A. C. J. E. j. o. a. p. (2005) Effect
of caffeine ingestion on lymphocyte counts and subset activation in vivo
following strenuous cycling. 93 (5-6), 606-613.
Bøhn, S. K., Ward, N. C., Hodgson, J.
M. and Croft, K. D. (2012) Effects of tea and coffee on cardiovascular
disease risk. Food & Function 3 (6), 575-591.
Bruce, M., Scott, N., Shine, P. and
Lader, M. J. A. o. G. P. (1992) Anxiogenic effects of caffeine in
patients with anxiety disorders. 49 (11), 867-869.
Cao, B., Wang, Y., Wen, D., Liu, W.,
Wang, J., Fan, G., Ruan, L., Song, B., Cai, Y., Wei, M., Li, X., Xia,
J., Chen, N., Xiang, J., Yu, T., Bai, T., Xie, X., Zhang, L., Li, C.,
Yuan, Y., Chen, H., Li, H., Huang, H., Tu, S., Gong, F., Liu, Y., Wei,
Y., Dong, C., Zhou, F., Gu, X., Xu, J., Liu, Z., Zhang, Y., Li, H.,
Shang, L., Wang, K., Li, K., Zhou, X., Dong, X., Qu, Z., Lu, S., Hu, X.,
Ruan, S., Luo, S., Wu, J., Peng, L., Cheng, F., Pan, L., Zou, J., Jia,
C., Wang, J., Liu, X., Wang, S., Wu, X., Ge, Q., He, J., Zhan, H., Qiu,
F., Guo, L., Huang, C., Jaki, T., Hayden, F. G., Horby, P. W., Zhang, D.
and Wang, C. (2020a) A Trial of Lopinavir–Ritonavir in Adults
Hospitalized with Severe Covid-19.
Cao, Y. C., Deng, Q. X. and Dai, S.
X. (2020b) Remdesivir for severe acute respiratory syndrome coronavirus
2 causing COVID-19: An evaluation of the evidence. Travel Med
Infect Dis , 101647.
Chan, J. F.-W., Yuan, S., Kok, K.-H.,
To, K. K.-W., Chu, H., Yang, J., Xing, F., Liu, J., Yip, C. C.-Y., Poon,
R. W.-S., Tsoi, H.-W., Lo, S. K.-F., Chan, K.-H., Poon, V. K.-M., Chan,
W.-M., Ip, J. D., Cai, J.-P., Cheng, V. C.-C., Chen, H., Hui, C. K.-M.
and Yuen, K.-Y. (2020) A familial cluster of pneumonia associated with
the 2019 novel coronavirus indicating person-to-person transmission: a
study of a family cluster. The Lancet 395 (10223), 514-523.
Channappanavar, R., Fehr, A. R.,
Vijay, R., Mack, M., Zhao, J., Meyerholz, D. K., Perlman, S. J. C. h.
and microbe (2016) Dysregulated type I interferon and inflammatory
monocyte-macrophage responses cause lethal pneumonia in
SARS-CoV-infected mice. 19 (2), 181-193.
Chavez-Valdez, R., Wills-Karp, M.,
Ahlawat, R., Cristofalo, E. A., Nathan, A. and Gauda, E. B. J. P. r.
(2009) Caffeine modulates TNF-α production by cord blood monocytes: the
role of adenosine receptors. 65 (2), 203.
Chen, N., Zhou, M., Dong, X., Qu, J.,
Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y. and Wei, Y. J. T. L.
(2020) Epidemiological and clinical characteristics of 99 cases of 2019
novel coronavirus pneumonia in Wuhan, China: a descriptive study. 395
(10223), 507-513.
Cheng, V. C., Lau, S. K., Woo, P. C.
and Yuen, K. Y. J. C. m. r. (2007) Severe acute respiratory syndrome
coronavirus as an agent of emerging and reemerging infection. 20 (4),
660-694.
Childs, E. and de Wit, H. (2008)
Enhanced mood and psychomotor performance by a caffeine-containing
energy capsule in fatigued individuals. Experimental and Clinical
Psychopharmacology 16 (1), 13.
Clark, R. H., Bloom, B. T., Spitzer,
A. R. and Gerstmann, D. R. (2006) Reported medication use in the
neonatal intensive care unit: data from a large national data set.Pediatrics 117 (6), 1979-87.
Clerici, M., Piconi, S., Balotta, C.,
Trabattoni, D., Capetti, A., Fusi, M. L., Ruzzante, S., Longhi, R.,
Colombo, M. C. and Moroni, M. (1997) Pentoxifylline improves
cell-mediated immunity and reduces human immunodeficiency virus (HIV)
plasma viremia in asymptomatic HIV-seropositive persons. Journal
of Infectious Diseases 175 (5), 1210-1215.
Coccheri, S. and Bignamini, A. A.
(2016) Pharmacological adjuncts for chronic venous ulcer healing .
SAGE Publications Sage UK: London, England.
Cohen, J. and Normile, D. (2020)New SARS-like virus in China triggers alarm . American Association
for the Advancement of Science.
Conti, P., Ronconi, G., Caraffa, A.,
Gallenga, C., Ross, R., Frydas, I., Kritas, S. J. J. o. b. r. and
agents, h. (2020) Induction of pro-inflammatory cytokines (IL-1 and
IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2):
anti-inflammatory strategies. 34 (2).
Corbel, M., Boichot, E. and Lagente,
V. (2000) Role of gelatinases MMP-2 and MMP-9 in tissue remodeling
following acute lung injury. Brazilian Journal of Medical and
Biological Research 33 (7), 749-754.
Dahl, J., You, J. and Benjamin, T. L.
J. J. o. v. (2005) Induction and utilization of an ATM signaling pathway
by polyomavirus. 79 (20), 13007-13017.
Daniel, R., Marusich, E., Argyris,
E., Zhao, R. Y., Skalka, A. M. and Pomerantz, R. J. J. J. o. v. (2005)
Caffeine inhibits human immunodeficiency virus type 1 transduction of
nondividing cells. 79 (4), 2058-2065.
Dekker, J., Hooper, S. B., van
Vonderen, J. J., Witlox, R. S., Lopriore, E. and Te Pas, A. B. J. P. r.
(2017) Caffeine to improve breathing effort of preterm infants at birth:
a randomized controlled trial. 82 (2), 290-296.
Deree, J., Martins, J., De Campos,
T., Putnam, J. G., Loomis, W. H., Wolf, P. and Coimbra, R. (2007)
Pentoxifylline attenuates lung injury and modulates transcription factor
activity in hemorrhagic shock. Journal of Surgical Research 143
(1), 99-108.
Dettelbach, H. R. and Aviado, D. M.
(1985) Clinical pharmacology of pentoxifylline with special reference to
its hemorrheologic effect for the treatment of intermittent
claudication. The Journal of Clinical Pharmacology 25 (1), 8-26.
Dobson, N. R., Patel, R. M., Smith,
P. B., Kuehn, D. R., Clark, J., Vyas-Read, S., Herring, A., Laughon, M.
M., Carlton, D. and Hunt, C. E. J. T. J. o. p. (2014) Trends in caffeine
use and association between clinical outcomes and timing of therapy in
very low birth weight infants. 164 (5), 992-998. e3.
Doyen, D., Moceri, P., Ducreux, D.
and Dellamonica, J. (2020) Myocarditis in a patient with COVID-19: a
cause of raised troponin and ECG changes. Lancet .
Duan, K., Liu, B., Li, C., Zhang, H.,
Yu, T., Qu, J., Zhou, M., Chen, L., Meng, S., Hu, Y., Peng, C., Yuan,
M., Huang, J., Wang, Z., Yu, J., Gao, X., Wang, D., Yu, X., Li, L.,
Zhang, J., Wu, X., Li, B., Xu, Y., Chen, W., Peng, Y., Hu, Y., Lin, L.,
Liu, X., Huang, S., Zhou, Z., Zhang, L., Wang, Y., Zhang, Z., Deng, K.,
Xia, Z., Gong, Q., Zhang, W., Zheng, X., Liu, Y., Yang, H., Zhou, D.,
Yu, D., Hou, J., Shi, Z., Chen, S., Chen, Z., Zhang, X. and Yang, X.
(2020) Effectiveness of convalescent plasma therapy in severe COVID-19
patients. Proceedings of the National Academy of Sciences 117
(17), 9490.
Fazely, F., Dezube, B., Allen-Ryan,
J., Pardee, A. and Ruprecht, R. (1991) Pentoxifylline (Trental)
decreases the replication of the human immunodeficiency virus type 1 in
human peripheral blood mononuclear cells and in cultured T cells [see
comments].
Fernandes, J. L., de Oliveira, R. T.
D., Mamoni, R. L., Coelho, O. R., Nicolau, J. C., Blotta, M. H. S. and
Serrano Jr, C. V. (2008) Pentoxifylline reduces pro-inflammatory and
increases anti-inflammatory activity in patients with coronary artery
disease—a randomized placebo-controlled study. Atherosclerosis196 (1), 434-442.
Fleming, C. M., He, H., Ciota, A.,
Perkins, D. and Finn, P. W. (2001) Administration of pentoxifylline
during allergen sensitization dissociates pulmonary allergic
inflammation from airway hyperresponsiveness. The Journal of
Immunology 167 (3), 1703-1711.
Gao, J., Tian, Z. and Yang, X. J. B.
t. (2020) Breakthrough: Chloroquine phosphate has shown apparent
efficacy in treatment of COVID-19 associated pneumonia in clinical
studies.
Gautret, P., Lagier, J.-C., Parola,
P., Meddeb, L., Mailhe, M., Doudier, B., Courjon, J., Giordanengo, V.,
Vieira, V. E. and Dupont, H. T. J. I. j. o. a. a. (2020)
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results
of an open-label non-randomized clinical trial. 105949.
González-Amaro, R., Portales-Pérez,
D., Baranda, L., Redondo, J. M., Martínez-Martínez, S., Yáñez-Mó, M.,
García-Vicuña, R., Cabañas, C. and Sánchez-Madrid, F. (1998)
Pentoxifylline inhibits adhesion and activation of human T lymphocytes.The Journal of Immunology 161 (1), 65-72.
González-Espinoza, L., Rojas-Campos,
E., Medina-Pérez, M., Peña-Quintero, P., Gómez-Navarro, B. and
Cueto-Manzano, A. M. J. N. D. T. (2012) Pentoxifylline decreases serum
levels of tumor necrosis factor alpha, interleukin 6 and C-reactive
protein in hemodialysis patients: results of a randomized double-blind,
controlled clinical trial. 27 (5), 2023-2028.
Graham, R. L. and Baric, R. S. (2010)
Recombination, reservoirs, and the modular spike: mechanisms of
coronavirus cross-species transmission. Journal of virology 84
(7), 3134-3146.
Grein, J., Ohmagari, N., Shin, D.,
Diaz, G., Asperges, E., Castagna, A., Feldt, T., Green, G., Green, M. L.
and Lescure, F.-X. J. N. E. J. o. M. (2020) Compassionate use of
remdesivir for patients with severe COVID-19.
Guo, H., Callaway, J. B. and Ting, J.
P. J. N. m. (2015) Inflammasomes: mechanism of action, role in disease,
and therapeutics. 21 (7), 677.
Gupta, M., George, A., Sen, R., Rath,
S., Durdik, J. M. and Bal, V. (1999) Presence of pentoxifylline during T
cell priming increases clonal frequencies in secondary proliferative
responses and inhibits apoptosis. The Journal of Immunology 162
(2), 689-695.
Haas, F., Bevelaqua, F., Levin, N.,
Solazar-Schicchi, J., Reggiani, J. L., Axen, K. and Pineda, H. (1990)
Pentoxifylline improves pulmonary gas exchange. Chest 97 (3),
621-627.
Harris, S., Rasyid, A., Nurhayati, E.
and Prihartono, J. (2017) Selected benefits of pentoxifylline in acute
ischemic stroke management: consideration of risk factors. Health
Science International Conference (HSIC 2017). Atlantis Press.
HAYASHI, M., TSUCHIYA, H., YAMAMOTO,
N., KARITA, M., SHIRAI, T., NISHIDA, H., TAKEUCHI, A. and TOMITA, K. J.
A. r. (2005) Caffeine-potentiated chemotherapy for metastatic carcinoma
and lymphoma of bone and soft tissue. 25 (3C), 2399-2405.
Henderson-Smart, D. and Davis, P. J.
T. C. L. (2001) Prophylactic methylxanthine for extubation in preterm
infants (Cochrane Review). (4).
Hoffmann, M., Kleine-Weber, H.,
Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S.,
Herrler, G., Wu, N.-H. and Nitsche, A. J. C. (2020) SARS-CoV-2 cell
entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven
protease inhibitor.
Hong, H., Wang, Y., Chung, H. T. and
Chen, C. J. (2020) Clinical characteristics of novel coronavirus disease
2019 (COVID-19) in newborns, infants and children. Pediatr
Neonatol 61 (2), 131-132.
Horrigan, L. A., Kelly, J. P. and
Connor, T. J. J. I. i. (2004) Caffeine suppresses TNF-α production via
activation of the cyclic AMP/protein kinase A pathway. 4 (10-11),
1409-1417.
Horrigan, L. A., Kelly, J. P.,
Connor, T. J. J. P. and therapeutics (2006) Immunomodulatory effects of
caffeine: friend or foe? 111 (3), 877-892.
Hsu, C. Y., Norris, J., Hogan, E.,
Bladin, P., Dinsdale, H., Yatsu, F., Earnest, M., Scheinberg, P.,
Caplan, L. and Karp, H. (1988) Pentoxifylline in acute nonhemorrhagic
stroke. A randomized, placebo-controlled double-blind trial.Stroke 19 (6), 716-722.
Huang, C., Wang, Y., Li, X., Ren, L.,
Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J. and Gu, X. (2020) Clinical
features of patients infected with 2019 novel coronavirus in Wuhan,
China. The Lancet 395 (10223), 497-506.
Imai, Y., Kuba, K., Neely, G. G.,
Yaghubian-Malhami, R., Perkmann, T., van Loo, G., Ermolaeva, M.,
Veldhuizen, R., Leung, Y. C. and Wang, H. J. C. (2008) Identification of
oxidative stress and Toll-like receptor 4 signaling as a key pathway of
acute lung injury. 133 (2), 235-249.
Jaruvongvanich, V., Sanguankeo, A.,
Klomjit, N., Upala, S. J. C., hepatology, r. i. and gastroenterology
(2017) Effects of caffeine consumption in patients with chronic
hepatitis C: A systematic review and meta-analysis. 41 (1), 46-55.
Jobe, A. H. (2017) Caffeine: A
Lung Drug for All Very Low Birth Weight Preterm Infants? , American
Thoracic Society.
Joob, B. and Wiwanitkit, V. (2020)
COVID-19 can present with a rash and be mistaken for dengue. J Am
Acad Dermatol 82 (5), e177.
Josset, L., Menachery, V. D.,
Gralinski, L. E., Agnihothram, S., Sova, P., Carter, V. S., Yount, B.
L., Graham, R. L., Baric, R. S. and Katze, M. G. J. M. (2013) Cell host
response to infection with novel human coronavirus EMC predicts
potential antivirals and important differences with SARS coronavirus. 4
(3), e00165-13.
Jung, S., Kim, M. H., Park, J. H.,
Jeong, Y. and Ko, K. S. J. J. o. m. f. (2017) Cellular antioxidant and
anti-inflammatory effects of coffee extracts with different roasting
levels. 20 (6), 626-635.
Kelley, J. (1990) Cytokines of the
lung. Am Rev Respir Dis 141 (3), 765-788.
Kimura, H., Tsuchiya, H., Shirai, T.,
Nishida, H., Hayashi, K., Takeuchi, A., Ohnari, I. and Tomita, K. J. J.
o. O. S. (2009) Caffeine-potentiated chemotherapy for metastatic
osteosarcoma. 14 (5), 556-565.
Klok, F., Kruip, M., van der Meer,
N., Arbous, M., Gommers, D., Kant, K., Kaptein, F., van Paassen, J.,
Stals, M. and Huisman, M. (2020) Incidence of thrombotic complications
in critically ill ICU patients with COVID-19. Thrombosis
Research .
Köroğlu, Ö. A., MacFarlane, P. M.,
Balan, K. V., Zenebe, W. J., Jafri, A., Martin, R. J. and Kc, P. J. N.
(2014) Anti-inflammatory effect of caffeine is associated with improved
lung function after lipopolysaccharide-induced amnionitis. 106 (3),
235-240.
Lai, C.-C., Shih, T.-P., Ko, W.-C.,
Tang, H.-J. and Hsueh, P.-R. (2020) Severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The
epidemic and the challenges. International Journal of
Antimicrobial Agents 55 (3), 105924.
Lam, A. and Newhouse, M. T. J. C.
(1990) Management of asthma and chronic airflow limitation: are
methylxanthines obsolete? 98 (1), 44-52.
Lamkanfi, M., Dixit, V. M. J. A. r.
o. c. and biology, d. (2012) Inflammasomes and their roles in health and
disease. 28, 137-161.
Lara, D. R. J. J. o. A. s. d. (2010)
Caffeine, mental health, and psychiatric disorders. 20 (s1), S239-S248.
Li, H., Tan, G., Tong, L., Han, P.,
Zhang, F., Liu, B. and Sun, X. (2016) Pentoxifylline inhibits pulmonary
inflammation induced by infrarenal aorticcross-clamping dependent of
adenosine receptor A2A. American journal of translational
research 8 (5), 2210.
Li, J., Li, G., Hu, J.-L., Fu, X.-H.,
Zeng, Y.-J., Zhou, Y.-G., Xiong, G., Yang, N., Dai, S.-S. and He, F.-T.
J. E. j. o. p. (2011) Chronic or high dose acute caffeine treatment
protects mice against oleic acid-induced acute lung injury via an
adenosine A2A receptor-independent mechanism. 654 (3), 295-303.
Li, W., Moore, M. J., Vasilieva, N.,
Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L.,
Luzuriaga, K. and Greenough, T. C. J. N. (2003) Angiotensin-converting
enzyme 2 is a functional receptor for the SARS coronavirus. 426 (6965),
450-454.
Lilly, C. M., Sandhu, J. S.,
Ishizaka, A., Harada, H., Yonemaru, M., Larrick, J. W., Shi, T.-X.,
O’HANLEY, P. T. and Raffin, T. A. (1989) Pentoxifylline Prevents Tumor
Necrosis Factor-induced Lung Injury1-3. Am Rev Respir Dis 139,
1361-1368.
Lipton, R. B., Diener, H. C.,
Robbins, M. S., Garas, S. Y. and Patel, K. (2017) Caffeine in the
management of patients with headache. J Headache Pain 18 (1),
107.
Liu, Y., Yang, Y., Zhang, C., Huang,
F., Wang, F., Yuan, J., Wang, Z., Li, J., Li, J. and Feng, C. J. S. C.
L. S. (2020) Clinical and biochemical indexes from 2019-nCoV infected
patients linked to viral loads and lung injury. 63 (3), 364-374.
Magnusson, M., Höglund, P.,
Johansson, K., Jönsson, C., Killander, F., Malmström, P., Weddig, A. and
Kjellén, E. (2009) Pentoxifylline and vitamin E treatment for prevention
of radiation-induced side-effects in women with breast cancer: a phase
two, double-blind, placebo-controlled randomised clinical trial (Ptx-5).European Journal of Cancer 45 (14), 2488-2495.
Maia, L. and De Mendonça, A. J. E. J.
o. N. (2002) Does caffeine intake protect from Alzheimer’s disease? 9
(4), 377-382.
Manzini, S., Perretti, F., Abelli,
L., Evangelista, S., Seeds, E. A. and Page, C. P. J. E. j. o. p. (1993)
Isbufylline, a new xanthine derivative, inhibits airway
hyperresponsiveness and airway inflammation in guinea pigs. 249 (3),
251-257.
Martín, J. F. B., Jiménez, J. L. and
MuEóz-Fernández, A. (2003) Pentoxifylline and severe acute respiratory
syndrome (SARS): a drug to be considered. Medical Science Monitor9 (6), SR29-SR34.
Matthay, M. A., Aldrich, J. M. and
Gotts, J. E. J. T. L. R. M. (2020) Treatment for severe acute
respiratory distress syndrome from COVID-19.
Mehta, P., McAuley, D. F., Brown, M.,
Sanchez, E., Tattersall, R. S. and Manson, J. J. (2020) COVID-19:
consider cytokine storm syndromes and immunosuppression. The
Lancet .
Mensah-Brown, E., Grujicic, S. S.,
Maksimovic, D., Jasima, A., Shahin, A. and Lukic, M. (2002)
Downregulation of apoptosis in the target tissue prevents low-dose
streptozotocin-induced autoimmune diabetes. Molecular immunology38 (12-13), 941-946.
Misirlioglu, C. H., Demirkasimoglu,
T., Kucukplakci, B., Sanri, E. and Altundag, K. (2007) Pentoxifylline
and alpha-tocopherol in prevention of radiation-induced lung toxicity in
patients with lung cancer. Medical oncology 24 (3), 308-311.
Montravers, P., Fagon, J.-Y.,
Gilbert, C., Blanchet, F., Novara, A. and Chastre, J. (1993) Pilot study
of cardiopulmonary risk from pentoxifylline in adult respiratory
distress syndrome. Chest 103 (4), 1017-1022.
Moschino, L., Zivanovic, S., Hartley,
C., Trevisanuto, D., Baraldi, E. and Roehr, C. C. J. E. O. R. (2020)
Caffeine in preterm infants: where are we in 2020? 6 (1).
Murayama, M., Tsujimoto, K., Uozaki,
M., Katsuyama, Y., Yamasaki, H., Utsunomiya, H. and Koyama, A. H. J. M.
m. r. (2008) Effect of caffeine on the multiplication of DNA and RNA
viruses. 1 (2), 251-255.
Murthy, S., Gomersall, C. D. and
Fowler, R. A. (2020) Care for Critically Ill Patients With COVID-19.JAMA .
Okuno, T., Sugiyama, T., Tominaga,
M., Kojima, S. and Ikeda, T. (2002) Effects of Caffeine on
Microcirculation of the Human Ocular Fundus. Japanese Journal of
Ophthalmology 46 (2), 170-176.
Olson, N. and Consigli, R. J. A. j.
o. v. r. (1979) Production of labile Newcastle disease virus progeny
after infection of chicken embryo cells in the presence of caffeine. 40
(3), 387-392.
Ou, X., Liu, Y., Lei, X., Li, P., Mi,
D., Ren, L., Guo, L., Guo, R., Chen, T. and Hu, J. J. N. C. (2020)
Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and
its immune cross-reactivity with SARS-CoV. 11 (1), 1-12.
Pal, R., Chaudhary, M. J., Tiwari, P.
C., Nath, R., Babu, S. and Pant, K. K. (2016) Pharmacological studies on
the anti-inflammatory and immunomodulatory role of pentoxifylline and
its interaction with nitric oxide (NO) in experimental arthritis in
rats. Inflammopharmacology 24 (5), 221-231.
Pauwels, R. J. C. (1987) The effects
of theophylline on airway inflammation. 92 (1), 32S-37S.
Poulakis, N., Androutsos, G., Kazi,
D., Bastas, A., Provata, A., Bitsakou, C., Kontozoglou, T.,
Polyzogopoulou, C. and Tassiopoulou, A. (1999) The differential effect
of pentoxifylline on cytokine production by alveolar macrophages and its
clinical implications. Respiratory medicine 93 (1), 52-57.
Poyiadji, N., Shahin, G., Noujaim,
D., Stone, M., Patel, S. and Griffith, B. (2020) COVID-19–associated
acute hemorrhagic necrotizing encephalopathy: CT and MRI features.Radiology , 201187.
Qin, C., Zhou, L., Hu, Z., Zhang, S.,
Yang, S., Tao, Y., Xie, C., Ma, K., Shang, K. and Wang, W. J. C. I. D.
(2020) Dysregulation of immune response in patients with COVID-19 in
Wuhan, China.
Recalcati, S. (2020) Cutaneous
manifestations in COVID-19: a first perspective. Journal of the
European Academy of Dermatology and Venereology n/a (n/a).
Rogers, M. C. and Williams, J. V.
(2018) Quis Custodiet Ipsos Custodes? Regulation of Cell-Mediated Immune
Responses Following Viral Lung Infections. Annual review of
virology 5, 363-383.
Ruan, Q., Yang, K., Wang, W., Jiang,
L. and Song, J. (2020a) Clinical predictors of mortality due to COVID-19
based on an analysis of data of 150 patients from Wuhan, China.Intensive care medicine , 1-3.
Ruan, Q., Yang, K., Wang, W., Jiang,
L. and Song, J. J. I. c. m. (2020b) Clinical predictors of mortality due
to COVID-19 based on an analysis of data of 150 patients from Wuhan,
China. 1-3.
Samieirad, S., Afrasiabi, H., Tohidi,
E., Qolizade, M., Shaban, B., Hashemipour, M. A. and Shirvan, I. D. J.
J. o. C.-M. S. (2017) Evaluation of caffeine versus codeine for pain and
swelling management after implant surgeries: A triple blind clinical
trial. 45 (10), 1614-1621.
Sarma, J. V. and Ward, P. A. J. C.
P. (2011) Oxidants and redox signaling in acute lung injury. 1 (3),
1365-1381.
Sayed, R., El Wakeel, L., Saad, A.
S., Kelany, M. and El-Hamamsy, M. (2020) Pentoxifylline and vitamin E
reduce the severity of radiotherapy-induced oral mucositis and dysphagia
in head and neck cancer patients: a randomized, controlled study.Medical Oncology 37 (1), 8.
Sebastian, L., Desai, A.,
Madhusudana, S. N. and Ravi, V. (2009) Pentoxifylline inhibits
replication of Japanese encephalitis virus: a comparative study with
ribavirin. International journal of antimicrobial agents 33 (2),
168-173.
Sharp, C., Millar, A. B. and
Medford, A. R. (2015) Advances in understanding of the pathogenesis of
acute respiratory distress syndrome. Respiration 89 (5), 420-434.
Shaw, S. M., Shah, M. K., Williams,
S. G. and Fildes, J. E. J. E. j. o. h. f. (2009) Immunological
mechanisms of pentoxifylline in chronic heart failure. 11 (2), 113-118.
Shen, C., Zhang, Z., Xie, T., Ji,
J., Xu, J., Lin, L., Yan, J., Kang, A., Dai, Q. and Dong, Y. J. F. i. p.
(2020) Rhein Suppresses Lung Inflammatory Injury Induced by Human
Respiratory Syncytial Virus Through Inhibiting NLRP3 Inflammasome
Activation via NF-κB Pathway in Mice. 10, 1600.
Shiraki, K. and Rapp, F. J. I.
(1988) Effects of caffeine on herpes simplex virus. 29 (4), 235-240.
Shulla, A., Heald-Sargent, T.,
Subramanya, G., Zhao, J., Perlman, S. and Gallagher, T. J. J. o. v.
(2011) A transmembrane serine protease is linked to the severe acute
respiratory syndrome coronavirus receptor and activates virus entry. 85
(2), 873-882.
Sibille, Y. and Reynolds, H. Y.
(1990) Macrophages and Polymorphonuclear neutrophils in lung defense and
Injury1-2. Am Rev Respir Dis 141, 471-501.
Smits, S. L., de Lang, A., van den
Brand, J. M., Leijten, L. M., van IJcken, W. F., Eijkemans, M. J., van
Amerongen, G., Kuiken, T., Andeweg, A. C. and Osterhaus, A. D. J. P. p.
(2010) Exacerbated innate host response to SARS-CoV in aged non-human
primates. 6 (2).
Sugiyama, K., Noda, Y., He, P. J.
B., biotechnology, and biochemistry (2001) Suppressive effect of
caffeine on hepatitis and apoptosis induced by tumor necrosis factor-α,
but not by the anti-Fas antibody, in mice. 65 (3), 674-677.
Sullivan, G. W., Luong, L. S.,
Carper, H. T., Barnes, R. C. and Mandell, G. L. J. I. (1995)
Methylxanthines with adenosine alter TNFα-primed PMN activation. 31 (1),
19-29.
Sullivan, P., Jaffar, Z., Page, C.,
Costello, J., Bekir, S. and Jeffery, P. J. T. L. (1994)
Anti-inflammatory effects of low-dose oral theophylline in atopic
asthma. 343 (8904), 1006-1008.
Sunil, V. R., Vayas, K. N.,
Cervelli, J. A., Malaviya, R., Hall, L., Massa, C. B., Gow, A. J.,
Laskin, J. D. and Laskin, D. L. (2014) Pentoxifylline attenuates
nitrogen mustard-induced acute lung injury, oxidative stress and
inflammation. Experimental and molecular pathology 97 (1), 89-98.
Suresh, R., Vig, M., Bhatia, S.,
Goodspeed, E. P., John, B., Kandpal, U., Srivastava, S., George, A.,
Sen, R. and Bal, V. (2002) Pentoxifylline functions as an adjuvant in
vivo to enhance T cell immune responses by inhibiting activation-induced
death. The Journal of Immunology 169 (8), 4262-4272.
Talik, P., Krzek, J., Ekiert, R. J.
S. and Reviews, P. (2012) Analytical techniques used for determination
of methylxanthines and their analogues—Recent advances. 41 (1), 1-61.
Tate, M. D., Ong, J. D., Dowling, J.
K., McAuley, J. L., Robertson, A. B., Latz, E., Drummond, G. R., Cooper,
M. A., Hertzog, P. J. and Mansell, A. J. S. r. (2016) Reassessing the
role of the NLRP3 inflammasome during pathogenic influenza A virus
infection via temporal inhibition. 6, 27912.
Thébaud, B. and Abman, S. H. (2007)
Bronchopulmonary dysplasia: where have all the vessels gone? Roles of
angiogenic growth factors in chronic lung disease. American
journal of respiratory and critical care medicine 175 (10), 978-985.
Tilley, S. L. (2011) Methylxanthines
in Asthma. Methylxanthines. Berlin, Heidelberg: Springer Berlin
Heidelberg. 439-456.
Tobinick, E. J. C. m. r. and opinion
(2004) TNF-[alpha] inhibition for potential therapeutic modulation
of SARS coronavirus infection. 20 (1), 39.
Tofovic, S. P., Zacharia, L.,
Carcillo, J. A. and Jackson, E. K. J. S. (2001) Inhibition of adenosine
deaminase attenuates endotoxin-induced release of cytokines in vivo in
rats. 16 (3), 196-202.
Tong, Z., Dai, H., Chen, B., Abdoh,
Z., Guzman, J. and Costabel, U. (2003) Inhibition of cytokine release
from alveolar macrophages in pulmonary sarcoidosis by pentoxifylline:
comparison with dexamethasone. Chest 124 (4), 1526-1532.
Torii, K., Iida, K.-i., Miyazaki,
Y., Saga, S., Kondoh, Y., Taniguchi, H., Taki, F., Takagi, K.,
Matsuyama, M. and Suzuki, R. (1997) Higher concentrations of matrix
metalloproteinases in bronchoalveolar lavage fluid of patients with
adult respiratory distress syndrome. American journal of
respiratory and critical care medicine 155 (1), 43-46.
Tynell, J., Westenius, V., Rönkkö,
E., Munster, V. J., Melén, K., Österlund, P. and Julkunen, I. (2016)
Middle East respiratory syndrome coronavirus shows poor replication but
significant induction of antiviral responses in human monocyte-derived
macrophages and dendritic cells. The Journal of general virology97 (Pt 2), 344.
van Koert, R. R., Bauer, P. R.,
Schuitema, I., Sander, J. W. and Visser, G. H. (2018) Caffeine and
seizures: A systematic review and quantitative analysis. Epilepsy
Behav 80, 37-47.
Wallis, R., Nsubuga, P., Whalen, C.,
Mugerwa, R., Okwera, A., Oette, D., Jackson, J., Johnson, J. and Ellner,
J. (1996) Pentoxifylline Therapy in Human Immunodeficiency
Virus—Seropositive Persons with Tuberculosis: A Randomized, Controlled
Trial. Journal of Infectious Diseases 174 (4), 727-733.
Wang, L., He, W., Yu, X., Hu, D.,
Bao, M., Liu, H., Zhou, J. and Jiang, H. (2020a) Coronavirus Disease
2019 in elderly patients: characteristics and prognostic factors based
on 4-week follow-up. Journal of Infection .
Wang, M., Cao, R., Zhang, L., Yang,
X., Liu, J., Xu, M., Shi, Z., Hu, Z., Zhong, W. and Xiao, G. (2020b)
Remdesivir and chloroquine effectively inhibit the recently emerged
novel coronavirus (2019-nCoV) in vitro. Cell Research 30 (3),
269-271.
Welsh, E. J., Bara, A., Barley, E.
and Cates, C. J. (2010) Caffeine for asthma. Cochrane Database of
Systematic Reviews (1).
Wen, W. X., Lee, S. Y., Siang, R.
and Koh, R. Y. J. A. i. t. (2017) Repurposing pentoxifylline for the
treatment of fibrosis: an overview. 34 (6), 1245-1269.
Whitfield, K., Rambaldi, A.,
Wetterslev, J. and Gluud, C. (2009) Pentoxifylline for alcoholic
hepatitis. Cochrane database of systematic reviews (4).
Wu, D., Yang, X. O. J. J. o. M.,
Immunology and Infection (2020a) TH17 responses in cytokine storm of
COVID-19: An emerging target of JAK2 inhibitor Fedratinib.
Wu, J., Yan, Z., Schwartz, D. E.,
Yu, J., Malik, A. B. and Hu, G. J. T. J. o. I. (2013) Activation of
NLRP3 inflammasome in alveolar macrophages contributes to mechanical
stretch-induced lung inflammation and injury. 190 (7), 3590-3599.
Wu, Y., Xu, X., Chen, Z., Duan, J.,
Hashimoto, K., Yang, L., Liu, C. and Yang, C. (2020b) Nervous system
involvement after infection with COVID-19 and other coronaviruses.Brain, Behavior, and Immunity .
Xu, X., Han, M., Li, T., Sun, W.,
Wang, D., Fu, B., Zhou, Y., Zheng, X., Yang, Y., Li, X., Zhang, X., Pan,
A. and Wei, H. (2020) Effective treatment of severe COVID-19 patients
with tocilizumab. Proceedings of the National Academy of
Sciences , 202005615.
Yamazaki, Z. and Tagaya, I. J. J. o.
G. V. (1980) Antiviral effects of atropine and caffeine. 50 (2),
429-431.
Yang, C.-Y., Chen, C.-S., Yiang,
G.-T., Cheng, Y.-L., Yong, S.-B., Wu, M.-Y. and Li, C.-J. (2018) New
insights into the immune molecular regulation of the pathogenesis of
acute Respiratory Distress Syndrome. International journal of
molecular sciences 19 (2), 588.
Yang, R.-Z., Lee, M.-J., Hu, H.,
Pollin, T. I., Ryan, A. S., Nicklas, B. J., Snitker, S., Horenstein, R.
B., Hull, K. and Goldberg, N. H. J. P. m. (2006) Acute-phase serum
amyloid A: an inflammatory adipokine and potential link between obesity
and its metabolic complications. 3 (6).
Ye, M., Ren, Y. and Lv, T. (2020)
Encephalitis as a clinical manifestation of COVID-19. Brain,
Behavior, and Immunity .
Zhao, W., Ma, L., Cai, C. and Gong,
X. J. I. j. o. b. s. (2019) Caffeine inhibits NLRP3 inflammasome
activation by suppressing MAPK/NF-κB and A2aR signaling in LPS-Induced
THP-1 macrophages. 15 (8), 1571.
Zhu, N., Zhang, D., Wang, W., Li,
X., Yang, B., Song, J., Zhao, X., Huang, B., Shi, W. and Lu, R. (2020) A
novel coronavirus from patients with pneumonia in China, 2019. New
England Journal of Medicine .
Zito, P. M. and Murgia III, R. D.
(2018) Pentoxifylline (Trental) in Venous Insufficiency and Venous Leg
Ulcers. Journal of the Dermatology Nurses’ Association 10 (6),
294-296.
Zumla, A., Chan, J. F., Azhar, E.
I., Hui, D. S. and Yuen, K. Y. (2016) Coronaviruses - drug discovery and
therapeutic options. Nat Rev Drug Discov 15 (5), 327-47.