Histological analysis
The mice were sacrificed 3 hours after the final injection of poly (I:C) or oral administration of K. pneumoniae . Pancreatic samples were subjected to fixation with 10% formalin followed by hematoxylin and eosin (H&E) staining; subsequently, pathological assessment was done by using a scoring system for AIP in accordance with previous reports [14, 16, 20]. Pancreas inflammation was scored as follows: 0, pancreas without mononuclear cell infiltration; 1, mononuclear cell aggregation and/or infiltration within the interstitium without parenchymal destruction; 2, focal parenchymal destruction with mononuclear cell infiltration; 3, diffuse parenchymal destruction but with retention of some intact parenchymal areas; 4, destruction of almost all pancreatic tissue, except for the pancreatic islets, or its replacement with fibrosis or adipose tissue [14, 16, 20]. At least two histological microscopy images (Biozero, BZ-8100, Keyence) were captured from each slide.