3.3 BCG consensus gene signature
Our workflow starts with the prioritization of a gene signature to study BCG’s network pharmacology. First, we derived a consensus gene signature (CGS) for BCG based on GEO’s dataset GSE58636. Details on BCG-CGS signature are found in table S1 (Supporting Information). Twenty-two differentially-expressed genes across all 4 experiments (2 Groups x 2 time points discussed in Methods) formed BCG’s consensus gene signature (BCG-CGS) shown in Figure 2A.