† Predicted activity of the key hub by causal reasoning is denoted by – if the hub is inhibited, and denoted by + if the hub is activated.
‡ Correct/total network predictions: correct for the genes in the dataset predicted correctly; total for the total number of genes in the causal reasoning network.
§ Calculation distance: Using causal reasoning one-step key hubs are defined as statistically significant transcriptional factors that are associated with experimental differential expressed genes regulation. Two-step and three-step key hubs are distant key hubs that regulate one-step transcriptional factors.
*P -value calcualted for the polynomial test.
Table 2. Small-molecule BCG mimics with potential antiviral effects.