What is the mechanism underlying eosinopenia in COVID-19
patients?
Eosinopenia is commonly reported in severe
COVID-19.54,55 The underlying mechanisms are largely
unknown and most likely multifactorial. A number of possible
explanations have been proposed: decreased eosinophilopoiesis; defective
eosinophil egression from the bone marrow; and eosinophil apoptosis
induced by type 1 IFN released during the acute
infection.50 Also, increased eosinophil migration and
retention within inflamed tissues has been
described,56 but disputed for the aforementioned
reasons.51