What is meant by CSS?
CSS is associated with a wide variety of diseases, both infectious and
noninfectious. It is a complex cascade of multicellular activation
events that leads to an excessive or uncontrolled release of
proinflammatory cytokines. CSS-associated inflammation begins at a local
site and spreads throughout the body via the systemic circulation and
can cause multi-organ failure and
hyper-ferritinemia.49,67