The generation of B-cell memory contributes to long-term
immunity. Has the extent and quality of SARS-CoV-2 memory responses been
evaluated?
B cell receptor-sequencing has been conducted in the blood of COVID-19
patients. Naive B cells exhibited little clonal expansion, whereas
CD27+CD38+ memory B cells showed the highest expansion levels among
diverse B cell subsets. COVID-19 patients had significantly expanded
specific B-cell receptor clones compared to those in the healthy
controls. These findings suggest that B cells experience unique clonal
variable, diversity, and joining gene segment rearrangements upon
SARS-CoV-2 infection.42 The lifespan and functionality
of these B cells remain to be elucidated.