Title: Notch4, uncovering an immunomodulator in allergic asthma
Authors: Beatriz Moyaa, Manali
Mukherjeeb and Parameswaran Nairb
a. Department of Allergy, Hospital Universitario 12 de Octubre, Madrid,
Spain
b. Division of Respirology, Department of Medicine, McMaster University,
Hamilton & Firestone Institute for Respiratory Health, St Joseph’s
Healthcare, Hamilton, ON, Canada
Correspondence to : Beatriz Moya. Allergy Department. Hospital
Universitario 12 de Octubre, Madrid, Spain
Email:drbeatrizmoya@gmail.com
Acknowledgements : Dr. Mukherjee is supported by investigator
award from Canadian Institutes of Health Research and Canadian Allergy,
Asthma, and Immunology Foundation. She has received honorarium from AZ,
GSK and her university has received grants from Methapharm Speciality
Pharmaceuticals. Dr. Nair is supported by the Frederick E. Hargreave
Teva Innovation Chair in Airway Diseases. He has received honoraria from
AZ, Sanofi, Teva, Merck, Novartis and Equillium and his university has
received research grants from AZ, Teva, Sanofi, Novartis, BI and
Methapharm. The authors recognize Dr. Anna Globinska for graphical
abstract design and Dr. Rodrigo Jiménez-Saiz for critical review of the
manuscript.
Keywords: Allergic asthma; Airway inflammation; Th2 cell; Th17
cell; Treg cell; Notch4 receptor
Abbreviations: Th, T helper; UFPs, pollutant ultrafine
particles; AMs, alveolar macrophages; Treg cells, regulatory T cells;
ILC2s, type 2 innate lymphoid cells; GDF15, cytokine growth and
differentiation factor 15; IL, interleukin; IL-6R, interleukin-6
receptor; IL-4R, interleukin-4 receptor
Word count: 918/1000