Molecular imaging for thrombosis
Thrombosis is a complex event, usually a result of undesired and uncontrolled platelet adhesion and aggregation, as well as increased thrombin formation and fibrin generation, within a vessel (Ziegler et al., 2019; Montague et al., 2020). Therefore, biomarkers of platelet activation and fibrin generation have attracted major attention as molecular targets for molecular imaging of arterial and venous thrombosis. As microthrombosis plays an important role in ischemic-reperfusion (I/R) injury, these targets have also been used to image, for example cardiac I/R injury (Ziegler et al., 2019).