Factor
Low induction therapy Tercile (n= 5867) Intermediate induction Tercile (n= 5829) High induction therapy Tercile (n= 5828)
p-value
Recipient Age, mean (SD) 54.1 (12.1) 53.5 (12.4)) 53.9 (12.3) 0.05
Gender, female 1528 (26.0%) 1532 (26.3%) 1527 (26.2%) 0.96
Rejection Risk score, median (IQR) 8 (6-9) 8 (6-10) 8 (6-9) <0.001
Induction therapy 767 (13.1%) 2697 (46.3%) 5066 (86.9%) <0.001
Basiliximab 452 (7.7%) 1,120 (41.5%) 3,314 (65.4%)
Thymoglobulin 256 (4.4%) 1,151 (19.7%) 1,360 (27%)
Ethnicity <0.001
Caucasian 3813 (65.0%) 3819 (65.5%) 3954 (67.8%)
African American 1240 (21.1%) 1210 (20.8%) 1283 (22.0%)
Hispanic 551 (9.4%) 509 (8.7%) 324 (5.6%)
Body Mass Index (kg/m2) 27.4 (4.9) 27.1 (4.8) 27.5 (5.1) <0.001
Diagnosis <0.001
Non-Ischemic Dilated Cardiomyopathy 2987 (50.9%) 3046 (52.3%) 3056 (52.4%)
Ischemic Cardiomyopathy 2167 (36.9%) 1989 (34.1%) 2104 (36.1%)
Congenital 127 (2.2%) 129 (2.2%) 188 (3.2%)
Restrictive Cardiomyopathy 89 (1.5%) 100 (1.7%) 53 (0.9%)
Hypertrophic Cardiomyopathy 122 (2.1%) 182 (3.1%) 135 (2.3%)
Valvular 179 (3.1%) 218 (3.7%) 180 (3.1%)
Status 1A 3812 (65.0%) 3716 (63.8%) 3696 (63.4%) 0.18
Class I PRA > 20% 321 (5.5%) 337 (5.8%) 354 (6.1%) 0.38
Class II PRA > 20% 228 (3.9%) 263 (4.5%) 242 (4.2%) 0.24
Diabetes Mellitus 1726 (29.4%) 1571 (27.0%) 1647 (28.3%) 0.01
Intra-Aortic Balloon Pump 312 (5.3%) 201 (3.4%) 320 (5.5%) <0.001
Inotropes at listing 1809 (30.8%) 1969 (33.8%) 2083 (35.7%) <0.001
Serum Creatinine in mg/dL, mean (SD) 1.20 (.4) 1.22(.4) 1.24(.5) <0.001
Pre-Transplant Mechanical Ventilation 36 (0.6%) 82 (1.4%) 83 (1.4%) <0.001
Transfusions While Listed 1350 (23.0%) 1301 (22.3%) 1406 (24.1%) 0.06
Pre-Transplant Dialysis 52 (0.9%) 59 (1.0%) 39 (0.7%) 0.13
Left Ventricular Assist Device Support 1774 (30.2%) 1305 (22.4%) 1677 (28.8%) <0.001
Heartmate 2 1466 (25.0%) 949 (16.3%) 1246 (21.4%)
Heartmate 3 69 (1.2%) 43 (0.7%) 51 (0.9%)
HeartWare 239 (4.1%) 313 (5.4%) 380 (6.5%)
HLA mismatch (>3) 4200 (71.6%) 4761 (81.7%) 4729 (81.1%) <0.001
Gender mismatch 4359 (74.3%) 4392 (75.3%) 4531 (77.7%) <0.001
CMV match 3062 (52.2%) 3049 (52.3%) 2957 (50.7%) 0.17
Donor-to-Recipient Weight Ratio, mean (SD) 1.01 (.24) 1.03 (.24) 1.01 (.23) <0.001