Outcomes and Sub-analysis
Patients were stratified into low and high-risk cohorts based on the
peak preoperative troponin level, with the threshold for stratification
centered around the median troponin level for the study cohort. The
primary outcome of this study was long-term major adverse cardiac and
cerebrovascular events (MACCE), which is a composite of death,
myocardial infarction, stroke, or need for repeat revascularization
procedures. Other outcomes investigated included short and long-term
survival, postoperative complications, and intensive care unit and
hospital length of stay. Predictors of MACCE and mortality were also
modeled.
Preoperative peak troponin levels were also evaluated when modeled as a
continuous variable. A secondary sub-analysis was performed with a
clinically meaningful troponin threshold of 10.00 ng/mL to define high-
and low-risk cohorts as well. In this secondary analysis, long-term
MACCE and survival were analyzed and modeled using multivariable
analysis.