Genetic testing
Genetic testing with next generation sequence analysis was performed for
probands with diagnosis of BrS type-1 ECG. The panel of 14 genes
included: SCN5A, GPD1L, SCN10A, SCN1B, SCN2B, SCN3B, CACNA1C,
CACNB2, KCND3, CACNAD2, KCNJ8, KCNE3, SLMAP,
RANGRF.15 Sanger sequencing was performed for
confirmation of pathogenic or likely-pathogenic variants and for genetic
screening. Variants classification was based on American College of
Medical Genetics (ACMG) Guidelines.16