Conclusions
In summary, according to our study, patients with type-1 BrS had a low
rate of life-threatening events. Proband status and spontaneous type 1
ECG in conventional leads were more common in the symptomatic group.
Gender, family history of SCD, inducibility of ventricular
tachyarrhythmias during EPS, and presence of a SCN5A variant were not
predictors of symptoms. Patients with SCN5A-mediated BrS exhibited more
conduction abnormalities. More studies are still necessary to better
understand the gaps and to improve risk assessment in these challenging
patients with Brugada Syndrome.