Brugada et al16 FINGER11 PRELUDE17 Sieira et al18 Letsas et al15 GenBrA
Type of study SC MC MC SC SC SC
Year of publication 2003 2010 2012 2015 2019 -
Total patients 547 1029 308 404 111 138
Mean follow-up (mo) 24 31.9 36 74 55.2 67.9
Male, n (%) 408 (74.6) 745 (72) 247 (80) 235 (58.2) 86 (77.5) 101 (73.2)
Mean Age 41 45 47 43.2 45.3 41
Probands status, n (%) NA 808 (78) NA 129 (31.9) 109 (73.2)
Spontaneous type-1, n (%) 391 (71.5) 468 (45) 171 (56) 75 (18.6) 49 (44.14) 107 (77.5)
Symptoms, n (%) Syncope SCD 124 (22.7) 0 313 (30) 62 (6) 65 (21) 0 114 (28.6) 17 (4.2) 37 (33.3) - 13 (9.4) 9 (6.5)
Inducible VF/VT, n/N (%) 163/245 (66.5) 262/638 (41.1) 126/308 (41) 73/404 (18.1) 32/59 (54.2) 29/92 (31.5)
ICD, n (%) 177 (32.4) 551 (53.5) 137 (44) 168 (41.6) 34 (30.6) 47 (34.1)
Annual event rate, % 4.1 1.6 1.5 0.9 1.4 1.1