Genetic testing
Genetic testing with next generation sequence analysis was performed for probands with diagnosis of BrS type-1 ECG. The panel of 14 genes included: SCN5A, GPD1L, SCN10A, SCN1B, SCN2B, SCN3B, CACNA1C, CACNB2, KCND3, CACNAD2, KCNJ8, KCNE3, SLMAP, RANGRF.15 Sanger sequencing was performed for confirmation of pathogenic or likely-pathogenic variants and for genetic screening. Variants classification was based on American College of Medical Genetics (ACMG) Guidelines.16