Genetic Data
A total of 25 type-1 BrS patients (probands and relatives) carried SCN5A
pathogenic or likely pathogenic variants. There was no difference in the
clinical presentation between SCN5A mutation carriers and noncarriers
(p=0.770). Otherwise, SCN5A carriers had a higher frequency of aVR sign
(58.3% vs 13.6%; p <0.001), S wave (75% vs 48.5%, p =
0.013) and QRS-f (29.2% vs 7.5%; p = 0.025). The HV interval was
longer in SCN5A carriers (66ms vs 49ms; p<0.001). These
genotype-phenotype associations are shown in Table 4.