References
1. Wherry EJ. T cell exhaustion. Nature Immunology. 2011;12(6):492-9. doi:10.1038/ni.2035
2. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5
3. Liu K, Chen Y, Lin R, Han K. Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients. Journal of Infection. 2020;80(6):e14-e8. doi: 10.1016/j.jinf.2020.03.005
4. Li T, Wu N, Dai Y, Qiu Z, Han Y, Xie J, et al. Reduced Thymic Output Is a Major Mechanism of Immune Reconstitution Failure in HIV-Infected Patients After Long-term Antiretroviral Therapy. Clinical Infectious Diseases. 2011;53(9):944-51. doi:10.1093/cid/cir552
5. Yager EJ, Ahmed M, Lanzer K, Randall TD, Woodland DL, Blackman MA. Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. Journal of Experimental Medicine. 2008;205(3):711-23. doi:10.1084/jem.20071140
6. Garaci E. From thymus to cystic fibrosis: the amazing life of thymosin alpha 1. Expert Opinion on Biological Therapy. 2018;18(sup1):9-11. doi:10.1080/14712598.2018.1484447
7. Matteucci C, Grelli S, Balestrieri E, Minutolo A, Argaw-Denboba A, Macchi B, et al. Thymosin alpha 1 and HIV-1: recent advances and future perspectives. Future Microbiology. 2017;12(2):141-55. doi:10.2217/fmb-2016-0125
8. Liu Y, Pang Y, Hu Z, Wu M, Wang C, Feng Z, et al. Thymosin alpha 1 (Tα1) reduces the mortality of severe COVID-19 by restoration of lymphocytopenia and reversion of exhausted T cells. Clinical Infectious Diseases. 2020. doi:10.1093/cid/ciaa630
9. McLane LM, Abdel-Hakeem MS, Wherry EJ. CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer. Annual Review of Immunology. 2015;37(1):457-95. doi:10.1146/annurev-immunol-041015-055318
10. Serana F, Chiarini M, Zanotti C, Sottini A, Bertoli D, Bosio A, et al. Use of V(D)J recombination excision circles to identify T- and B-cell defects and to monitor the treatment in primary and acquired immunodeficiencies. Journal of Translational Medicine. 2013;11(1):119. doi:10.1186/1479-5876-11-119
11. Ji SM, Li LS, Sun QQ, Chen JS, Sha GZ, Liu ZH. Immunoregulation of Thymosin α 1 Treatment of Cytomegalovirus Infection Accompanied With Acute Respiratory Distress Syndrome After Renal Transplantation. Transplantation Proceedings. 2007;39(1):115-9. doi: 10.1016/j.transproceed.2006.10.005