IDEA AND THEORY
So the idea is how to attack the lipoprotein membrane of
Corona virus for 24 hours in the airway of the infected person either in
mild, moderate or severe cases who are on Ventilators. At the same time
the thermal attack should be safe to the respiratory tissues.
As the Virus inside respiratory tract is protected by inside secretions
so we should calculate the actual required temperature essential to heat
upper and lower airways’ secretions to the degree that could cause Viral
Coat destruction. This could decrease the extracellular viruses count
and could decrease the overall viral load. (Francois 2020 ) Hence
the fat density is 0.9 of water (Ali 2018 ) so if we could raise
the temperature in respiratory tract secretion 1C this will deliver
1.333 °C thermal injury to the lipoprotein coat of the virus. So the
infected person with Corona needs to inhale 48.76˷ 49 °C of continuous
hot Vapor with ≥ 90% humidity for 15 minutes! This is unsafe for the
lungs. This degree is thermal cytotoxic for human lungs. This would be
more than the thermal threshold for alveolar damage even if delivered in
short time about 15 minutes. The question to be urgently investigated is
why not deliver 38°C or more - 44°C or less (which safer to the lung) of
humid Vapor into patient’s airway? Author thinks this could be a great
idea for the management of COVID_19.
This proposed thermal attack will eliminate a lot of extra-cellular
viruses, inside respiratory tract secretions. It literally means
decreasing the COVID_19 Viruses load (Francois 2020 ) and allows
body immune system to combat the virus with almost no or a little
cytokine storm. This idea can simply quiet the morbidity and mortality
curve.
Although studies are not mentioning the viral count/each infected air
droplet, this proposed heating approach, also may decrease the virulence
of infection, when the viral count in the droplets are decreased with
subsequent decrease in spread of infection to contacts.
These methods could be designed carefully for investigation by Heath
providers who treating Victims with COVID_19 in different models of
degree, duration and rate of lung tissue heating in randomized control
study groups till complete recovery. This Idea could be also designed
and delivered for patients on Ventilators according to each case
clinical data. According to general data obtained from ICU specialized
article, (Haitham 2014 ) physicians can keep the ventilation
humidity at 100-120% and temperature at 40.7 C = (55X0.74) if they
adjusted the heater at 55 to compensate the tube loss (0.74%). They
could deliver different degrees of heating and humidity in the study.The
article propose a theory of Safe heat thermolysis Attack of Corona virus
COVID_19, to destruct its lipoprotein coat and that could make sense in
the investigational studies.
Something to be mentioned; In Vitro studies (El Badrawy 2018;Maya 2018; Yonekura, 2020 ) recommended the Idea of
Application of sodium bicarbonate (SB) in the heated humidified Vapor as
an adjuvant to the kill the respiratory tract pathogens, via simple
inhalation or even bronchoscopy or endotracheal tube may provide an
additional help in management of COVID_19. Correction of Stress
acidosis could not be neglected in patients with respiratory Failure.
Parenteral SB will not affect the intracellular PH=7.2 but will correct
the blood PH when needed.
All health governments must now take decisive action to investigate
every possible assumption to combated COVID_19 (Lancet ed. 2020 ;
Lo, V.T., 2020 )
Acknowledgment: To Mrs Nashwa Saleh for her help and
support.
Conflict of interest statement: The Author has no any
conflict of interest
Disclosure: The author has no financial interest to
declare in relation to the content of this article.
Data availability is available on request
Ethical Statement is not applicable