Comparing biomarkers between peanut allergic and peanut sensitised tolerant groups
PA children had significantly higher peanut SPT than PS children at 12m, 36m and 7-11y (Table 1). Median peanut-sIgE levels were also significantly different between PA vs PS groups at 36m and 7-11y. This was further reflected in the peanut component data with the PA group having significantly higher Ara h 1-sIgE, Ara h 2-sIgE and Ara h 6-sIgE levels at the 7-11y time point compared to the PS group. Interestingly, at 36m of age, the PA group already had higher Ara h 2-sIgE levels compared to the PS group (4.0kUA/L vs 0.04kUA/L, p<0.001) and this increased and remained significantly higher as they got older (16.3kUA/L vs 0.06kUA/L, p<0.001 at 7-11y). The %CD63-positive LAD2 cells following peanut stimulation was higher in the PA group at the 3-year and 7-11year time points compared to the PS group.
Table 1: Comparison of biomarkers across time between Peanut Allergic vs Peanut sensitized not allergic patients with allergic status determined at 7-11 years. Mast cell activation following stimulation with 1000ng/ml of peanut extract.