Peanut allergic status at the 7-11y time point
Persistent peanut allergy (n=18) New peanut allergy (n=2) Outgrown peanut allergy (n=1) No peanut allergy (n=27)
P value
Peanut SPT mm (IQR) Peanut SPT mm (IQR) Peanut SPT mm (IQR) Peanut SPT mm (IQR) Peanut SPT mm (IQR) Peanut SPT mm (IQR)
3 months* 12 months 36 months 7-11 years 0 (0, 0) 5.8 (3.5, 8) 8.8 (7, 10.5) 9.3 (7.5, 10.5) 0 (0, 0) 1 (0, 2) 1.3 (0, 2.5) 7 (4, 10) – 5.5 8.0 0 0 (0, 2) 1 (0, 4.5) 1 (0, 5) 0 (0, 2) 0.02 <0.001 <0.001
Peanut specific IgE (kUA/L) Peanut specific IgE (kUA/L) Peanut specific IgE (kUA/L) Peanut specific IgE (kUA/L) Peanut specific IgE (kUA/L) Peanut specific IgE (kUA/L)
3 months 12 months 36 months 7-11 years 0.05 (0.0, 0.3) 1.5 (0.9, 7.2) 9.5 (6.1, 46.7) 30.0 (4.2, 85.4) 0.03 (0.03, 0.03) 0.4 (0.1, 0.8) 0.7 (0.2, 1.3) 11.7 (2.9, 20.5) 0.08 1.3 0.01 0.02 0.05 (0.0, 0.3) 1.6 (1.1, 5.4) 0.9 (0.2, 1.5) 0.6 (0.1, 4.9) 0.41 0.28 <0.001 <0.001
Peanut components specific IgE (kUA/L) Peanut components specific IgE (kUA/L) Peanut components specific IgE (kUA/L) Peanut components specific IgE (kUA/L) Peanut components specific IgE (kUA/L) Peanut components specific IgE (kUA/L)
3 months Ara h 1 Ara h 2 Ara h 3 Ara h 8 0.07 (0, 0.4) 0.01 (0.01, 2.0) 0.02 (0.002, 0.04) 0.003 (0.002, 0.005) 0.01 (0.01, 0.01) 0.01 (0.01, 0.01) 0.01 (0.01, 0.01) 0.01 (0.01, 0.01) 0.01 0.01 0.01 0.01 0.01 (0.01, 0.01) 0.01 (0.01, 0.01) 0.01 (0.01, 0.01) 0.01 (0.01, 0.01) 0.91 0.93 0.87 0.99
12 months Ara h 1 Ara h 2 Ara h 3 Ara h 8 0.3 (0.05, 4.0) 0.8 (0.07, 6.7) 0.08 (0.02, 0.3) 0.001 (0, 0.01) 0.3 (0.01, 0.6) 0.1 (0.01, 0.1) 0.02 (0.01, 0.03) 0.01 (0.01, 0.01) 0.06 1.7 0.01 0.01 0.2 (0.02, 0.6) 0.1 (0.01, 0.7) 0.1 (0.03, 0.4) 0.01 (0.01, 0.01) 0.47 0.13 0.26 0.92
36 months Ara h 1 Ara h 2 Ara h 3 Ara h 8 0.04, 2.4) 9.3 (1.4, 31.9) 0.05 (0.02, 0.6) 0.01 (0, 0.01) 0.04 (0.02, 0.1) 0.03 (0.01, 0.04) 0.03 (0.03, 0.03) 0.05 (0.01, 0.09) 0.01 0.01 0.01 0.01 0.1 (0.03, 0.2) 0.04 (0.01, 0.2) 0.1 (0.05, 0.2) 0.04 (0.01, 0.05) 0.21 <0.001 0.31 0.28
7-11 years Ara h 1 Ara h 2 Ara h 3 Ara h 6 Ara h 8 2.0 (0.1, 35.7) 19.8 (1.9, 60.5) 0.3 (0.01, 3.9) 13.0 (2.3, 32.4) 0.5 (0, 7.9) 1.3 (0.3, 2.4) 6.4 (0.1, 12.8) 0.19 (0.2, 0.3) 1.5 (0.05, 2.9) 48.7 (2.6, 94.9) 0.01 0.01 0.01 0.01 0.01 0.02 (0.01, 0.1) 0.04 (0.01, 0.1) 0.04 (0.01, 0.1) 0.04 (0.01, 0.1) 0.1 (0.01, 0.6) <0.001 <0.001 0.05 <0.001 0.16
Peanut-specific IgG4 and specific IgG4:IgE Ratios Peanut-specific IgG4 and specific IgG4:IgE Ratios Peanut-specific IgG4 and specific IgG4:IgE Ratios Peanut-specific IgG4 and specific IgG4:IgE Ratios Peanut-specific IgG4 and specific IgG4:IgE Ratios Peanut-specific IgG4 and specific IgG4:IgE Ratios
Peanut sIgG4 (g/L) 3 months 12 months 36 months 7-11 years 6.1 (0, 52.8) 202.9 (102, 436.8) 494.2 (215.9, 1800.6) 736.2 (217.2, 1361.3) 15.2 (15.2,15.3) 233.7 (37.1, 430.3) 121.1 (23.3, 218.8) 840.9 (840.9, 1613.4) - - 99.3 44.3 8.4 (0, 27.3) 84.8 (34.5, 506.9) 386.5 (96, 2171.5) 719 (127.9, 2685) 0.66 0.37 0.35 0.43
Peanut specific IgG4:IgE ratios 3 months 12 months 36 months 7-11 years 4.4 (0, 63.6) 30.4 (6.7, 78.2) 14.7 (7.5, 21.1) 10.4 (4.5, 37.4) 211.7 (211.1, 212.4) 213.2 (193.5, 232.9) 60.6 (51, 70.1) 21.3 (9.8, 32.8) - - 4135.9 1044.8 20.5 (0, 326.2) 17.9 (6.1, 296.4) 175.8 (39.6, 1222.7) 483 (30.4, 2448.0) 0.39 0.22 0.03 <0.01
Mast cell activation to peanut (%CD63+ LAD2 cells) Mast cell activation to peanut (%CD63+ LAD2 cells) Mast cell activation to peanut (%CD63+ LAD2 cells) Mast cell activation to peanut (%CD63+ LAD2 cells) Mast cell activation to peanut (%CD63+ LAD2 cells) Mast cell activation to peanut (%CD63+ LAD2 cells)
12 months 36 months 7-11 years 4.6 (0.16, 25.2) 17.8 (3.1, 30.3) 12.7 (7.6, 38.9) 0.1 (0.01, 0.2) 0.3 (0.3, 0.4) 0.2 (0.1, 0.4) – 0.01 0.5 0.3 (0.01, 3.3) 0.2 (0.01, 0.6) 0.2 (0.01, 0.8) 0.20 <0.001 <0.001
At the 3m time point, only children in the early introduction group had SPT performed. *At the 3m time point, only children in the early introduction group had SPT performed. *At the 3m time point, only children in the early introduction group had SPT performed. *At the 3m time point, only children in the early introduction group had SPT performed. *At the 3m time point, only children in the early introduction group had SPT performed. *At the 3m time point, only children in the early introduction group had SPT performed.