hat bilateral diffuse alveolar injury was accompanied by
cellular fibromyxoid exudation and interstitial mononuclear inflammatory
infiltration, suggesting that exudative inflammation was closely related
to the lung injury caused by covid-19 [35]. It’s reported that heart
injury occurred in 20-30% of patients, and caused 40% of patients die
[36]. The mechanism of heart injury is not yet clear. Some studies
have suggested that vasodilation, endothelial permeability and
inflammatory process after leukocyte recruitment caused by respiratory
failure and virus infection lead to cardiovascular stress and eventually
myocardial injury [37]. In this study, it was found that the three
prescriptions can maintain immune homeostasis, body temperature
homeostasis and promote injury repair. They played a regulatory role in
the entire disease process and presented a two-way regulatory feature.
And the three prescriptions all have the effect of regulating hypoxia
and the development of lung acinar. YQ also played a role in the
proliferation of cardiomyocytes, preventing the virus from attacking
heart. Moreover, the three can also regulate the stability of
coagulation function and slow down the damage of important organs. It’s
reported that in patients who died at the age of 60 and over, new
coronary pneumonia often occurs simultaneously with chronic diseases
such as tumor diseases [34]. Interestingly, the three also played a
role in tumor treatment pathways.
The study is also trying to demonstrate the core theory of traditional
Chinese medicine that is syndrome differentiation in the treatment of
diseases in a modern way. Syndrome differentiation is to diagnose the
cold, heat, or damp characteristics of the same disease according to the
symptoms that different patients with different constitutions showed.
Then the herbs with relatively cold or heat resistance properties are
selected, reflecting the same disease with different treatment.
Interestingly, we found that although the compositions of the three
herbal prescriptions were completely different, the functions, the
targets and pathways that affect the disease were the same. We also
found that the hub gene RB1, as a common gene to the three
prescriptions, was mainly enriched in viral infections and tumors, which
was also in line with our actual clinical practice. Because the theory
of treating diseases by traditional Chinese Medicine is based on the
symptoms of a single patient, so at a certain stage for different
diseases, patients showed similar symptoms and then the same kind of
herb prescriptions will be chosen. This is another core feature of
traditio