hat bilateral diffuse alveolar injury was accompanied by cellular fibromyxoid exudation and interstitial mononuclear inflammatory infiltration, suggesting that exudative inflammation was closely related to the lung injury caused by covid-19 [35]. It’s reported that heart injury occurred in 20-30% of patients, and caused 40% of patients die [36]. The mechanism of heart injury is not yet clear. Some studies have suggested that vasodilation, endothelial permeability and inflammatory process after leukocyte recruitment caused by respiratory failure and virus infection lead to cardiovascular stress and eventually myocardial injury [37]. In this study, it was found that the three prescriptions can maintain immune homeostasis, body temperature homeostasis and promote injury repair. They played a regulatory role in the entire disease process and presented a two-way regulatory feature. And the three prescriptions all have the effect of regulating hypoxia and the development of lung acinar. YQ also played a role in the proliferation of cardiomyocytes, preventing the virus from attacking heart. Moreover, the three can also regulate the stability of coagulation function and slow down the damage of important organs. It’s reported that in patients who died at the age of 60 and over, new coronary pneumonia often occurs simultaneously with chronic diseases such as tumor diseases [34]. Interestingly, the three also played a role in tumor treatment pathways.
The study is also trying to demonstrate the core theory of traditional Chinese medicine that is syndrome differentiation in the treatment of diseases in a modern way. Syndrome differentiation is to diagnose the cold, heat, or damp characteristics of the same disease according to the symptoms that different patients with different constitutions showed. Then the herbs with relatively cold or heat resistance properties are selected, reflecting the same disease with different treatment. Interestingly, we found that although the compositions of the three herbal prescriptions were completely different, the functions, the targets and pathways that affect the disease were the same. We also found that the hub gene RB1, as a common gene to the three prescriptions, was mainly enriched in viral infections and tumors, which was also in line with our actual clinical practice. Because the theory of treating diseases by traditional Chinese Medicine is based on the symptoms of a single patient, so at a certain stage for different diseases, patients showed similar symptoms and then the same kind of herb prescriptions will be chosen. This is another core feature of traditio