Adrenaline dose for people taking beta-blockers
We did not identify robust comparative studies exploring the most
effective adrenaline dose.
It is unclear whether taking beta-blockers influences the number of
adrenaline doses needed because the certainty of evidence is very low
(supplement S5j). A case control study in adults found that
beta-blockers were associated with a 3% increase in the likelihood of
requiring more than one adrenaline dose (OR 1.26, 95% CI 0.58 to 2.75,
very low certainty). This was non-significant, even after adjusting for
age, sex, allergen and other conditions 11White JL, Greger KC,
Lee S, Kahoud RJ, Li JT, Lohse CM, Campbell RL. Patients taking
β-blockers do not require increased doses of epinephrine for
anaphylaxis. J Allergy Clin Immunol Pract 2018;6(5):1553-1558.e1.