Outcomes
Population
Absolute effect
Relative effect (95% CI)
Certainty of effect
Overall conclusion
Studies (participants)
Biphasic reactions associated with adrenaline
Children
Range 9% (p>0.05) to 18% (p<0.05) reduction
OR 0.08 from one study (0.014 to 0.43)
Very low
Unknown impact
2 case control (n = 269) (Manuyakorn 2015, Mehr 2009)
Biphasic reactions associated with adrenaline administered within 30 minutes of onset
Adults and children
23% reduction (p<0.05)
OR 3.39 (1.13 to 10.18)
Very Low
Unknown impact
1 case control (n = 430) (Liu 2020)
Hospital admissions associated with adrenaline administered before vs at ED
Children
26% reduction if administered before ED (p<0.05)
OR 0.25 (0.10 to 0.62)
Very Low
Unknown impact
1 case control (n = 384) (Fleming 2015)
Admission to ICU associated with adrenaline administered before vs at ED Children 0% - Very low Unknown impact 1 case control (n = 384) (Fleming 2015)
Overdose associated with intravenous bolus compared to intramuscular adrenaline
Adults and children
13% increase (p<0.05)
OR 61.3 (7.5 to infinity)
Very low
Unknown impact
1 case series (n = 301) (Campbell 2015)
Cardiovascular events associated with intravenous bolus compared to intramuscular adrenaline
Adults and children
8% increase (p<0.05)
OR 7.5 (1.6 to 35.3)
Very low
Unknown impact
1 case series (n = 301) (Campbell 2015)