Abstract
Objectives: The aim of this study was to investigate whether
the prevalence of group 2 innate lymphoid cells (ILC2s) in sinonasal
tissues or in peripheral blood is associated with the postoperative
outcome in chronic rhinosinusitis (CRS) patients.
Design: A cross-sectional study of CRS patients undergoing
endoscopic sinus surgery (ESS).
Setting: ”Blinded for review”.
Participants: Eleven patients with eosinophilic CRS (eCRS) and
ten patients with non-eCRS were recruited.
Main outcome measures: We examined the ILC2 prevalence in
sinonasal tissues and in peripheral blood before and after ESS.
Lund-Mackay computed tomography (LMK-CT) scores were used to evaluate
the postoperative outcomes; cases with more than 50% improvement were
categorized into the good outcome group, and cases with less than 50%
improvement were categorized into the poor outcome group.
Results: The ILC2 prevalence in sinonasal tissues was
correlated with that in preoperative blood in the eCRS and non-eCRS
patients. The ILC2 prevalence in sinonasal tissues and in preoperative
blood was not correlated with the pre- or postoperative LMK-CT scores.
Postoperatively, the ILC2
prevalence in blood was decreased in the eCRS and non-eCRS patients,
and
the
decrease was associated with the good outcome group, but not the poor
outcome group.
Conclusion: The decreased ILC2 prevalence in blood may be
related to good postoperative outcomes after ESS in eCRS and non-eCRS
patients.