Food allergy and overall risk of atopic disorders
There were no food allergy or food sensitization studies identified that examined fiber or prebiotic interventions. We identified 2 interventional studies of prebiotic supplementation in healthy infants reporting on general allergic outcomes. No difference in allergic outcomes at 5 years of age were noted among healthy infants given either non-hydrolyzed cow milk-based formula supplemented with neutral sc-GOS, lcFOS, pAOS, and compared to non-supplemented formula or breastfed children before the age of 8 weeks of life.58 However, healthy day-care children aged between 1-4 years given a cow’s milk-based beverage (CMBB) supplemented with docosahexaenoic acid, polydextrose, GOS, and yeast β-glucan, and additionally fortified with micronutrients (zinc, vitamin A, iron), 3 times/day for 28 weeks had fewer episodes of allergic manifestations in the skin and the respiratory tract, including allergic rhinitis or conjunctivitis, wheezing, allergic cough, eczema and urticaria (HR 0.64; CI 95% 0.47, 0.89; p=0.007).59