References:
1. Sigismund S, Avanzato D, Lanzetti
L: Emerging functions of the EGFR in cancer . Molecular
oncology 2018, 12 (1):3-20.
2. Seshacharyulu P, Ponnusamy MP,
Haridas D, Jain M, Ganti AK, Batra SK: Targeting the EGFR
signaling pathway in cancer therapy . Expert opinion on
therapeutic targets 2012, 16 (1):15-31.
3. Graus-Porta D, Beerli RR, Daly JM,
Hynes NE: ErbB-2, the preferred heterodimerization partner of
all ErbB receptors, is a mediator of lateral signaling . The EMBO
journal 1997, 16 (7):1647-1655.
4. Moasser MM: The oncogene
HER2: its signaling and transforming functions and its role in human
cancer pathogenesis . Oncogene 2007, 26 (45):6469-6487.
5. Seshadri R, Firgaira FA, Horsfall
DJ, McCaul K, Setlur V, Kitchen P: Clinical significance of
HER-2/neu oncogene amplification in primary breast cancer. The South
Australian Breast Cancer Study Group . Journal of clinical
oncology : official journal of the American Society of Clinical
Oncology 1993, 11 (10):1936-1942.
6. Nakajima M, Sawada H, Yamada Y,
Watanabe A, Tatsumi M, Yamashita J, Matsuda M, Sakaguchi T, Hirao T,
Nakano H: The prognostic significance of amplification and
overexpression of c-met and c-erb B-2 in human gastric carcinomas .Cancer 1999, 85 (9):1894-1902.
7. Yoshizawa A, Sumiyoshi S, Sonobe M,
Kobayashi M, Uehara T, Fujimoto M, Tsuruyama T, Date H, Haga H:HER2 status in lung adenocarcinoma: a comparison of
immunohistochemistry, fluorescence in situ hybridization (FISH),
dual-ISH, and gene mutations . Lung cancer 2014,85 (3):373-378.
8. La Salvia A, Lopez-Gomez V,
Garcia-Carbonero R: HER2-targeted therapy: an emerging strategy
in advanced colorectal cancer . Expert opinion on investigational
drugs 2019, 28 (1):29-38.
9. Slamon DJ, Leyland-Jones B, Shak S,
Fuchs H, Paton V, Bajamonde A, Fleming T, Eiermann W, Wolter J, Pegram Met al : Use of chemotherapy plus a monoclonal antibody
against HER2 for metastatic breast cancer that overexpresses HER2 .The New England journal of medicine 2001,344 (11):783-792.
10. Pivot X, Romieu G, Debled M,
Pierga JY, Kerbrat P, Bachelot T, Lortholary A, Espie M, Fumoleau P,
Serin D et al : 6 months versus 12 months of adjuvant
trastuzumab in early breast cancer (PHARE): final analysis of a
multicentre, open-label, phase 3 randomised trial . Lancet 2019,393 (10191):2591-2598.
11. van Ramshorst MS, van der Voort
A, van Werkhoven ED, Mandjes IA, Kemper I, Dezentje VO, Oving IM,
Honkoop AH, Tick LW, van de Wouw AJ et al : Neoadjuvant
chemotherapy with or without anthracyclines in the presence of dual HER2
blockade for HER2-positive breast cancer (TRAIN-2): a multicentre,
open-label, randomised, phase 3 trial . The Lancet Oncology 2018,19 (12):1630-1640.
12. Valachis A, Nearchou A, Polyzos
NP, Lind P: Cardiac toxicity in breast cancer patients treated
with dual HER2 blockade . Int J Cancer 2013,133 (9):2245-2252.
13. Liberati A, Altman DG, Tetzlaff
J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen
J, Moher D: The PRISMA statement for reporting systematic
reviews and meta-analyses of studies that evaluate healthcare
interventions: explanation and elaboration . Bmj 2009,339 :b2700.
14. Moher D, Pham B, Jones A, Cook
DJ, Jadad AR, Moher M, Tugwell P, Klassen TP: Does quality of
reports of randomised trials affect estimates of intervention efficacy
reported in meta-analyses? Lancet 1998,352 (9128):609-613.
15. Sweeting MJ, Sutton AJ, Lambert
PC: What to add to nothing? Use and avoidance of continuity
corrections in meta-analysis of sparse data . Statistics in
medicine 2004, 23 (9):1351-1375.
16. Shao Z, Pang D, Yang H, Li W,
Wang S, Cui S, Liao N, Wang Y, Wang C, Chang YC et al :Efficacy, Safety, and Tolerability of Pertuzumab, Trastuzumab,
and Docetaxel for Patients With Early or Locally Advanced ERBB2-Positive
Breast Cancer in Asia: The PEONY Phase 3 Randomized Clinical Trial .JAMA oncology 2019.
17. Perez EA, Barrios C, Eiermann W,
Toi M, Im YH, Conte P, Martin M, Pienkowski T, Pivot XB, Burris HA, 3rdet al : Trastuzumab emtansine with or without pertuzumab
versus trastuzumab with taxane for human epidermal growth factor
receptor 2-positive advanced breast cancer: Final results from
MARIANNE . Cancer 2019, 125 (22):3974-3984.
18. Tabernero J, Hoff PM, Shen L,
Ohtsu A, Shah MA, Cheng K, Song C, Wu H, Eng-Wong J, Kim K et al :Pertuzumab plus trastuzumab and chemotherapy for HER2-positive
metastatic gastric or gastro-oesophageal junction cancer (JACOB): final
analysis of a double-blind, randomised, placebo-controlled phase 3
study . The Lancet Oncology 2018, 19 (10):1372-1384.
19. Rimawi M, Ferrero JM, de la
Haba-Rodriguez J, Poole C, De Placido S, Osborne CK, Hegg R, Easton V,
Wohlfarth C, Arpino G et al : First-Line Trastuzumab Plus
an Aromatase Inhibitor, With or Without Pertuzumab, in Human Epidermal
Growth Factor Receptor 2-Positive and Hormone Receptor-Positive
Metastatic or Locally Advanced Breast Cancer (PERTAIN): A Randomized,
Open-Label Phase II Trial . Journal of clinical oncology :
official journal of the American Society of Clinical Oncology 2018,36 (28):2826-2835.
20. Johnston SRD, Hegg R, Im SA, Park
IH, Burdaeva O, Kurteva G, Press MF, Tjulandin S, Iwata H, Simon SDet al : Phase III, Randomized Study of Dual Human
Epidermal Growth Factor Receptor 2 (HER2) Blockade With Lapatinib Plus
Trastuzumab in Combination With an Aromatase Inhibitor in Postmenopausal
Women With HER2-Positive, Hormone Receptor-Positive Metastatic Breast
Cancer: ALTERNATIVE . Journal of clinical oncology : official
journal of the American Society of Clinical Oncology 2018,36 (8):741-748.
21. von Minckwitz G, Procter M, de
Azambuja E, Zardavas D, Benyunes M, Viale G, Suter T, Arahmani A,
Rouchet N, Clark E et al : Adjuvant Pertuzumab and
Trastuzumab in Early HER2-Positive Breast Cancer . The New England
journal of medicine 2017, 377 (2):122-131.
22. Urruticoechea A, Rizwanullah M,
Im SA, Ruiz ACS, Lang I, Tomasello G, Douthwaite H, Badovinac Crnjevic
T, Heeson S, Eng-Wong J et al : Randomized Phase III Trial
of Trastuzumab Plus Capecitabine With or Without Pertuzumab in Patients
With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast
Cancer Who Experienced Disease Progression During or After
Trastuzumab-Based Therapy . Journal of clinical oncology :
official journal of the American Society of Clinical Oncology 2017,35 (26):3030-3038.
23. Perez EA, Barrios C, Eiermann W,
Toi M, Im YH, Conte P, Martin M, Pienkowski T, Pivot X, Burris H, 3rdet al : Trastuzumab Emtansine With or Without Pertuzumab
Versus Trastuzumab Plus Taxane for Human Epidermal Growth Factor
Receptor 2-Positive, Advanced Breast Cancer: Primary Results From the
Phase III MARIANNE Study . Journal of clinical oncology : official
journal of the American Society of Clinical Oncology 2017,35 (2):141-148.
24. Piccart-Gebhart M, Holmes E,
Baselga J, de Azambuja E, Dueck AC, Viale G, Zujewski JA, Goldhirsch A,
Armour A, Pritchard KI et al : Adjuvant Lapatinib and
Trastuzumab for Early Human Epidermal Growth Factor Receptor 2-Positive
Breast Cancer: Results From the Randomized Phase III Adjuvant Lapatinib
and/or Trastuzumab Treatment Optimization Trial . Journal of
clinical oncology : official journal of the American Society of Clinical
Oncology 2016, 34 (10):1034-1042.
25. Gianni L, Pienkowski T, Im YH,
Tseng LM, Liu MC, Lluch A, Staroslawska E, de la Haba-Rodriguez J, Im
SA, Pedrini JL et al : 5-year analysis of neoadjuvant
pertuzumab and trastuzumab in patients with locally advanced,
inflammatory, or early-stage HER2-positive breast cancer (NeoSphere): a
multicentre, open-label, phase 2 randomised trial . The Lancet
Oncology 2016, 17 (6):791-800.
26. Swain SM, Baselga J, Kim SB, Ro
J, Semiglazov V, Campone M, Ciruelos E, Ferrero JM, Schneeweiss A,
Heeson S et al : Pertuzumab, trastuzumab, and docetaxel in
HER2-positive metastatic breast cancer . The New England journal
of medicine 2015, 372 (8):724-734.
27. Bonnefoi H, Jacot W, Saghatchian
M, Moldovan C, Venat-Bouvet L, Zaman K, Matos E, Petit T, Bodmer A,
Quenel-Tueux N et al : Neoadjuvant treatment with
docetaxel plus lapatinib, trastuzumab, or both followed by an
anthracycline-based chemotherapy in HER2-positive breast cancer: results
of the randomised phase II EORTC 10054 study . Annals of oncology
: official journal of the European Society for Medical Oncology / ESMO2015, 26 (2):325-332.
28. de Azambuja E, Holmes AP,
Piccart-Gebhart M, Holmes E, Di Cosimo S, Swaby RF, Untch M, Jackisch C,
Lang I, Smith I et al : Lapatinib with trastuzumab for
HER2-positive early breast cancer (NeoALTTO): survival outcomes of a
randomised, open-label, multicentre, phase 3 trial and their association
with pathological complete response . The Lancet Oncology 2014,15 (10):1137-1146.
29. Swain SM, Kim SB, Cortes J, Ro J,
Semiglazov V, Campone M, Ciruelos E, Ferrero JM, Schneeweiss A, Knott Aet al : Pertuzumab, trastuzumab, and docetaxel for
HER2-positive metastatic breast cancer (CLEOPATRA study): overall
survival results from a randomised, double-blind, placebo-controlled,
phase 3 study . The Lancet Oncology 2013, 14 (6):461-471.
30. Robidoux A, Tang G, Rastogi P,
Geyer CE, Jr., Azar CA, Atkins JN, Fehrenbacher L, Bear HD, Baez-Diaz L,
Sarwar S et al : Lapatinib as a component of neoadjuvant
therapy for HER2-positive operable breast cancer (NSABP protocol B-41):
an open-label, randomised phase 3 trial . The Lancet Oncology2013, 14 (12):1183-1192.
31. Guarneri V, Frassoldati A,
Bottini A, Cagossi K, Bisagni G, Sarti S, Ravaioli A, Cavanna L,
Giardina G, Musolino A et al : Preoperative chemotherapy
plus trastuzumab, lapatinib, or both in human epidermal growth factor
receptor 2-positive operable breast cancer: results of the randomized
phase II CHER-LOB study . Journal of clinical oncology : official
journal of the American Society of Clinical Oncology 2012,30 (16):1989-1995.
32. Gianni L, Pienkowski T, Im YH,
Roman L, Tseng LM, Liu MC, Lluch A, Staroslawska E, de la Haba-Rodriguez
J, Im SA et al : Efficacy and safety of neoadjuvant
pertuzumab and trastuzumab in women with locally advanced, inflammatory,
or early HER2-positive breast cancer (NeoSphere): a randomised
multicentre, open-label, phase 2 trial . The Lancet Oncology2012, 13 (1):25-32.
33. Blackwell KL, Burstein HJ,
Storniolo AM, Rugo HS, Sledge G, Aktan G, Ellis C, Florance A, Vukelja
S, Bischoff J et al : Overall survival benefit with
lapatinib in combination with trastuzumab for patients with human
epidermal growth factor receptor 2-positive metastatic breast cancer:
final results from the EGF104900 Study . Journal of clinical
oncology : official journal of the American Society of Clinical
Oncology 2012, 30 (21):2585-2592.
34. Baselga J, Cortes J, Kim SB, Im
SA, Hegg R, Im YH, Roman L, Pedrini JL, Pienkowski T, Knott A et
al : Pertuzumab plus trastuzumab plus docetaxel for metastatic
breast cancer . The New England journal of medicine 2012,366 (2):109-119.
35. Baselga J, Bradbury I, Eidtmann
H, Di Cosimo S, de Azambuja E, Aura C, Gomez H, Dinh P, Fauria K, Van
Dooren V et al : Lapatinib with trastuzumab for
HER2-positive early breast cancer (NeoALTTO): a randomised, open-label,
multicentre, phase 3 trial . Lancet 2012,379 (9816):633-640.
36. Blackwell KL, Burstein HJ,
Storniolo AM, Rugo H, Sledge G, Koehler M, Ellis C, Casey M, Vukelja S,
Bischoff J et al : Randomized study of Lapatinib alone or
in combination with trastuzumab in women with ErbB2-positive,
trastuzumab-refractory metastatic breast cancer . Journal of
clinical oncology : official journal of the American Society of Clinical
Oncology 2010, 28 (7):1124-1130.
37. Xu B. LW, Zhang Q., Z. Shao,X.
Wang, H. Li, T. Sun, Y. Yin, H. Zheng, H. Zhang, T. Chan, G. Lei, E.
Restuccia: A phase III, randomized, double-blind, placebo
(Pla)-controlled study of pertuzumab (P) + trastuzumab (H) + docetaxel
(D) versus Pla + H+ D in previously untreated HER2-positive locally
recurrent/metastatic breast cancer (LR/MBC) (PUFFIN). Journal of
Clinical Oncology 2019, 37 (15_suppl):1026-1026
38. Fedele C, Riccio G, Malara AE,
D’Alessio G, De Lorenzo C: Mechanisms of cardiotoxicity
associated with ErbB2 inhibitors . Breast cancer research and
treatment 2012, 134 (2):595-602.
39. Mantarro S, Rossi M, Bonifazi M,
D’Amico R, Blandizzi C, La Vecchia C, Negri E, Moja L: Risk of
severe cardiotoxicity following treatment with trastuzumab: a
meta-analysis of randomized and cohort studies of 29,000 women with
breast cancer . Internal and emergency medicine 2016,11 (1):123-140.
40. Choi HD, Chang MJ:Cardiac toxicities of lapatinib in patients with breast cancer
and other HER2-positive cancers: a meta-analysis . Breast cancer
research and treatment 2017, 166 (3):927-936.
41. Gassmann M, Casagranda F, Orioli
D, Simon H, Lai C, Klein R, Lemke G: Aberrant neural and cardiac
development in mice lacking the ErbB4 neuregulin receptor .Nature 1995, 378 (6555):390-394.