Figure legends
Figure 1: Flow chart of study selection in the meta-analysis
Figure 2: incidence of LVEF and CHF associated with dual HER-2 blockade and anti-HER-2 monotherapy in breast cancer;
Figure 3: Risk of LVEF and CHF associated with dual HER-2 blockade versus anti-HER-2 monotherapy in breast cancer;
Supplemental figure 1: Funnel plot of publication bias for LVEF decline in the meta-analysis
Supplemental figure 2: : Funnel plot of publication bias for CHF in the meta-analysis