Sensitivity analysis
Sensitivity analyses using Mantel Haenszel or Inverse Variance model
showed that the risk of LVEF decline with dual HER-2 blockade was
1.19(95%CI: 1.02-1.41, p =0.031) and 1.18 (95%CI: 1.01-1.40,p =0.041). Similarly, sensitivity analyses using Mantel Haenszel
or Inverse Variance model showed that the risk of CHF associated with
dual HER-2 blockade was 1.48 (95%CI: 1.01-2.16, p =0.045) and
1.55(95%CI: 1.04-2.25, p =0.032) (supplemental table 1) when
compared to anti-HER2 monotherapy.