Condensed Abstract
A novel conductive hydrogel was developed as a method to treat
substrate-based arrhythmias by homogenizing conduction through disrupted
myocardium. In ex vivo canine hearts, the hydrogel was injected
evenly through ablated regions of myocardium. Electroanatomic activation
mapping of the epicardial surface demonstrated a shift in conduction to
surround edges following ablation of the region. Following injection of
the conductive hydrogel, conduction improved through the ablated region
approximating baseline in all 4 hearts. This proof-of-concept study
demonstrates that conductive hydrogel can be injected into acutely
disrupted myocardium to restore conduction.