Methods
We identified records of trials from online registries including Clinical trials.gov, the International clinical trials platform of the WHO, the EU clinical trials register and the Cochrane Central Register of Controlled Trials. We collated all registered trials and identified interventional studies focusing on therapeutic strategies. This identified 1835studies. After removing duplicates, we had 915 studies from where we selected 490 which focused on therapeutic interventions having further removed studies on preventative interventions and vaccine trials. Another 150 studies were removed which was based on Chinese traditional and complementary interventions, leaving a total of 228 studies from where we selected the 10 most drugs studies which was tested in 170 trials as shown in the PRISMA flow diagram(Figure 1 ).