Methods
We identified records of trials from online registries including
Clinical trials.gov, the International clinical trials platform of the
WHO, the EU clinical trials register and the Cochrane Central Register
of Controlled Trials. We collated all registered trials and identified
interventional studies focusing on therapeutic strategies. This
identified 1835studies. After removing duplicates, we had 915 studies
from where we selected 490 which focused on therapeutic interventions
having further removed studies on preventative interventions and vaccine
trials. Another 150 studies were removed which was based on Chinese
traditional and complementary interventions, leaving a total of 228
studies from where we selected the 10 most drugs studies which was
tested in 170 trials as shown in the
PRISMA flow diagram(Figure 1 ).