Background
Metabolic syndrome and obesity occur commonly in long-term pediatric
cancer survivors and exacerbate other chronic conditions. The intestinal
microbiome is associated with metabolic syndrome and obesity in the
general population, and is perturbed during cancer therapy. We aimed to
determine if long-term survivors of pediatric cancer would have reduced
bacterial microbiome diversity, and if these findings would be
associated with components of the metabolic syndrome, obesity, and
chronic inflammation.