Deterministic and probabilistic sensitivity analyses

The utility values resulted in the highest change in the ICER (Figure 3). In all evaluated analyses the SCIT+ICS remained cost-effective. Probabilistic sensitivity analyses indicated that SCIT+ICS was cost-effective in 95.2% of iterations when compared to ICS and 88.7% of iterations were associated to a gain in QALYs. The SCIT+ICS showed an increasing probability of being cost effective as the WTP threshold increased (See supplementary material 2).