As the entrance of visitors in Fernando de Noronha is strictly controlled, the adoption of simple educational strategies targeting the awareness of disease transmission or even appropriate testing of symptomatic visitors should be implemented during check-in and check-out procedures as part of a wider surveillance program. Moreover, it is suggested the implementation of an extensive One Health and Health Education Program to control leptospirosis that should involve different health professionals such as physicians, nurses, veterinarians, biologists and health agents.