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\begin{document}

\title{Sentinel lymph node biopsy versus selective neck dissection in patients
with early oral squamous cell carcinoma: a cost analysis}



\author[1]{Quitterie de Kerangal}%
\author[1]{Raissa Kapso}%
\author[1]{Stephane Temam}%
\author[2]{Jean-Marie Gouin}%
\author[1]{Jamila Marghadi}%
\author[3]{Sylvain Moriniere}%
\author[4]{Boris Laure}%
\author[1]{François Bidault}%
\author[1]{Odile Casiraghi}%
\author[1]{Julia Bonastre}%
\author[1]{Antoine Moya-Plana}%
\affil[1]{Gustave Roussy}%
\affil[2]{Regional University Hospital Centre Tours}%
\affil[3]{CHU Bretonneau}%
\affil[4]{CHRU Tours}%


\vspace{-1em}



  
  \date{May 25, 2024}


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\begin{abstract}
Objective: Sentinel lymph node biopsy (SLNB) seems as efficient as
selective neck dissection (SND) for the treatment of occult metastases
in T1-T2cN0 oral squamous cell carcinoma (SCC). The aim of our study was
to assess and compare the cost of these two surgical procedures.
Patients and methods: This retrospective cost analysis includes
consecutive patients treated between 2012 and 2017 in two French
hospitals either by SLNB or SND. Hospital cost (hospital stay for
initial surgery and re-hospitalizations over a period of 60 days after
the initial surgery), the length of hospital stay for the initial
surgery and the perioperative management were described and compared
between the two techniques. The propensity score regression adjustment
method was used to address selection bias. Results: Ninety-four patients
underwent SLNB procedure and seventy-seven patients underwent SND. The
length of hospital stay for initial surgery was lower in SLNB group: 5.8
days (SD: 3.8) versus 9.2 days (SD: 5) in the SND group. Hospital costs
were lower in SLNB group: \textbackslash{}euro7 489 (standard deviation:
\textbackslash{}euro3 691) versus \textbackslash{}euro8 886 (standard
deviation: \textbackslash{}euro4 381) but this difference was not
significant after propensity score regression adjustment. The rate of
complication, the delay of full oral feeding and postoperative drainage
were lower in SLNB group. Conclusion: SLNB in T1-T2cN0 oral SCC is less
invasive than SND with fewer complications, a shorter length of hospital
stay and favorable perioperative management. This study shows that this
technique could be also less expensive than SND.%
\end{abstract}%



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\verb`Table 3.docx`  available at \url{https://authorea.com/users/344638/articles/471073-sentinel-lymph-node-biopsy-versus-selective-neck-dissection-in-patients-with-early-oral-squamous-cell-carcinoma-a-cost-analysis}

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\verb`Table 5.docx`  available at \url{https://authorea.com/users/344638/articles/471073-sentinel-lymph-node-biopsy-versus-selective-neck-dissection-in-patients-with-early-oral-squamous-cell-carcinoma-a-cost-analysis}

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