Tigecycline reduces tumorigenesis in colorectal cancer via inhibition of cell proliferation and modulation of immune response.
Antonio Jesús Ruiz-Malagóna,b,*, Laura Hidalgo-Garcíaa,b,*, María Jesús Rodríguez-Sojoa,b, José Alberto Molina-Tijerasa,b, Federico Garcíab,c,d, Patricia Diez-Echavea,b, Teresa Vezzaa,b, Patricia Becerrab,e Juan Antonio Marchalb,f,g, Eduardo Redondo-Cerezob,h, Martin Hausmanni, Gerhard Rogleri,j, José Garrido-Mesak,#, María Elena Rodríguez-Cabezasa,b,#, Alba Rodríguez-Nogalesa,b,&, Julio Gálveza,b,l,&.
a Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, 18071-Granada, Spain.
b Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18012-Granada, Spain.
c Servicio Microbiología, Hospital Universitario Clínico San Cecilio, 18100-Granada, Spain.
d Ciber de Enfermedades Infecciosas, CiberInfecc.
e Servicio de Anatomía Patológica, Hospital Universitario Clínico San Cecilio, 18014 Granada, Spain.
f Biopathology and Regenerative Medicine Institute (IBIMER), Centre for Biomedical Research (CIBM), University of Granada, Granada E-18100, Spain
g Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada, E-18016, Spain.
h Servicio de Aparato Digestivo. Hospital Universitario Virgen de las Nieves, Granada, España.
i Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
jZurich Center for Integrative Human Physiology (ZIHP), University of Zurich, 8057, Zurich, Switzerland.
k The William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK
l Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD).
*Both authors contributed equally to the study.
&Both authors contributed equally to the supervision of the study.
#Correspondence authors: María Elena Rodríguez-Cabezas, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, 18071-Granada, Spain. merodri@ugr.es. Tel: +34958241519. ORCID: https://orcid.org/0000-0001-9085-8147. José Garrido-Mesa. Department of Medical & Molecular Genetics, School of Basic and Medical Biosciences, Faculty of Life Sciences & Medicine​. King’s College London, UK. j.garrido@kcl.ac.uk. ORCID: https://orcid.org/0000-0001-6420-9055.