Tigecycline reduces tumorigenesis in colorectal cancer via
inhibition of cell proliferation and modulation of immune response.
Antonio Jesús Ruiz-Malagóna,b,*, Laura
Hidalgo-Garcíaa,b,*, María Jesús
Rodríguez-Sojoa,b, José Alberto
Molina-Tijerasa,b, Federico
Garcíab,c,d, Patricia
Diez-Echavea,b, Teresa Vezzaa,b,
Patricia Becerrab,e Juan Antonio
Marchalb,f,g, Eduardo
Redondo-Cerezob,h, Martin Hausmanni,
Gerhard Rogleri,j, José
Garrido-Mesak,#, María Elena
Rodríguez-Cabezasa,b,#, Alba
Rodríguez-Nogalesa,b,&, Julio
Gálveza,b,l,&.
a Department of Pharmacology, Center for Biomedical
Research (CIBM), University of Granada, 18071-Granada, Spain.
b Instituto de Investigación Biosanitaria de Granada
(ibs.GRANADA), 18012-Granada, Spain.
c Servicio Microbiología, Hospital Universitario
Clínico San Cecilio, 18100-Granada, Spain.
d Ciber de Enfermedades Infecciosas, CiberInfecc.
e Servicio de Anatomía Patológica, Hospital
Universitario Clínico San Cecilio, 18014 Granada, Spain.
f Biopathology and Regenerative Medicine Institute
(IBIMER), Centre for Biomedical Research (CIBM), University of Granada,
Granada E-18100, Spain
g Department of Human Anatomy and Embryology, Faculty
of Medicine, University of Granada, Granada, E-18016, Spain.
h Servicio de Aparato Digestivo. Hospital
Universitario Virgen de las Nieves, Granada, España.
i Department of Gastroenterology and Hepatology,
University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091,
Zurich, Switzerland.
jZurich Center for Integrative Human Physiology
(ZIHP), University of Zurich, 8057, Zurich, Switzerland.
k The William Harvey Research Institute, Barts and the
London School of Medicine, Queen Mary University of London, London, UK
l Centro de Investigación Biomédica en Red de
Enfermedades Hepáticas y Digestivas (CIBEREHD).
*Both authors contributed equally to the study.
&Both authors contributed equally to the supervision
of the study.
#Correspondence authors: María Elena
Rodríguez-Cabezas, Department of Pharmacology, Center for Biomedical
Research (CIBM), University of Granada, 18071-Granada, Spain.
merodri@ugr.es. Tel: +34958241519. ORCID:
https://orcid.org/0000-0001-9085-8147. José Garrido-Mesa. Department of
Medical & Molecular Genetics, School of Basic and Medical Biosciences,
Faculty of Life Sciences & Medicine. King’s College London, UK.
j.garrido@kcl.ac.uk.
ORCID: https://orcid.org/0000-0001-6420-9055.