Conclusion:
This rigorously conducted RCT showed that folic acid has greater benefit in reducing Hot Flush Score in postmenopausal women when compared with placebo. However; the difference between groups did not reach statistical significance. While the study was unable to demonstrate an unequivocal benefit, folic acid supplementation represents a cheap, safe and well-tolerated alternative to conventional HRT, and it remains a potential option for those who are not able to take HRT such as breast cancer survivors. Definitive evidence of benefit would however require a larger study.