Main findings:
This RCT showed that folic acid gave greater benefit in reducing the Hot Flush Score in postmenopausal women when compared with placebo. However, the difference between the two groups did not reach statistical significance. There was no statistically significant difference in the secondary outcome measures except in the total and emotional Utian QoL scores at week 8 where a significant improvement was found in the folic acid group. However; this difference disappeared at week 12. This finding was not replicated in a multilevel mixed-effects model analysis.