RNA expression imputation with PrediXcan and their association with asthma
We imputed the RNA expression levels of genes on chromosome 6 for whole blood and lung tissue using PrediXcan20. This allows subject-level genes expression prediction for 48 human tissues with Genotype-Tissue Expression (GTEx) V7 data. Subsequently, linear regression was used to determine whether the predicted RNA expression is associated with asthma status. For linear regression, the top 20 PC scores, age and sex were included as covariates.