Statistical analysis
Statistical analysis was performed using the SPSS Software (version
25.0; SPSS Inc., Chicago, IL). Infants exclusively supported by HFNC and
those who required escalation to MV were divided in two groups and
demographic, clinical, laboratory and radiological features were
compared. Continuous variables values were expressed as mean ± SD or
median and range and compared using T-student or Mann-Whitney tests.
Categorical variables were expressed as number and percentages and
compared using chi-square test. P < 0.05 was considered
statistically significant. A multivariate logistic regression analysis
was performed to determine factors associated with HFNC failure, which
was defined as requirement for MV.