1. Introduction
Intratympanic dexamethasone(ITD) has been reported to be used to treat
Méniere’s disease, It is widely used in clinical due to its minor
systemic side effects, convenient way of administration which
dexamethasone can penetrate directly into the inner ear through the
round window membrane and effective treatment effect. However, ITD also
has adverse reactions that cannot be ignored, such as transient
dizziness and vertigo, pain, tongue numbness, bleeding, tinnitus and
persistent perforation. In addition, in our research center, external
auditory canal mycosis and tympanic membrane atrophy thinning can be
observed in some patients after ITD which has rarely been reported
before. Herein, we summarized the characteristics of the particular
complications we observed in our research center which preferred to
reflect the characteristics of patients in southern China due to their
origin.
Since 1985, Fradis M et al. used intratympanic lidocaine (ITL) to treat
Méniere’s disease, with an effective rate of over
67.8%[4]. ITL was also widely carried out in our
research center. In order to more accurately evaluate the complication
characteristics of Méniere’s disease patients treated with ITD, the
patients treated with ITL were set as randomized control.