Genotype-Phenotype Correlation
The dystrophin deficient cardiomyopathies, Becker’s and Duchenne Muscular Dystrophy differ in both genetic alteration, and residual protein function. Within each disease however, further attempts to correlate specific genotype and phenotype have been made16. Patients with sparing of certain crucial domains within the protein, or mutations which replace a single amino acid rather than disrupting the entire protein reading frame, trend towards having milder cardiac phenotype on magnetic resonance imaging17. While mutation analysis may help to predict age of onset of cardiomyopathy in the muscular dystrophy, arrhythmia burden has not included in these studies18,19.