a This loci was validated by Sanger sequencing.
b This loci was performed by evolutionary conservative analysis.
c The effect of the change of this mutation on the encoded protein structure.
d D: disease-causing, T: tolerated.
e N: polymorphism, A: disease causing automatic.
f Pro damaging: probable damaging; Pos damaging: Possible damaging.
g GERP++NR: GREP++ conservation score. The higher the value, the more conservative the loci.
h PhastCons100way_ver: conservative prediction in vertebrates in 100 vertebrates. The scores of PhastCons score ranged from 0 to 1, and the higher the values, the more conservative the loci.