Patients and clinical data
151 pregnancy women were excluded other liver disease, diagnosed as ICP on the basis of skin pruritus in combination with abnormal liver biochemistry indexes, e.g. TBA, ALT and AST, etc. In addition, 26 clinical features covering six main indicators of maternal and neonatal data, including patient basic features (age, gestational age and body mass index: BMI), ion concentration (K, Na, Cl, Ca, Mg, P), routine blood test (the counts of white blood cell: WBC, red blood cell: RBC, platelet: PLT, red blood cell distribution width.SD: RDW.SD), liver function index (TBA, ALT, AST, total bilirubin: TBIL, direct bilirubin: DBIL, indirect bilirubin: IDBIL), lipid index (CHOL, TG, high-density lipoprotein: HDL, low-density lipoprotein: LDL, uric acid) and outcomes of pregnant women and newborns (birth weight and bleeding amount), were recorded. Besides, we also recruited 1029 pregnancy women without ICP as negative controls.