a For fed-batch cultivations (Figure S5), the mean ± standard deviation for individual determinations is given (n=3).
b Process time is the sum of reactor setup and the actual fermentation
c Space time yield (STY) calculated according to Equation 1.
d Chemostat cultivations in which the cultivation period was limited to the phase before population collapse.
If long-term stability is only possible through reduced productivity, the question of process efficiency arises. In order to compare fed-batch and continuous production, we used the space-time-yield (STY; Equation 1) as the evaluation criterion.