a For fed-batch cultivations (Figure S5), the mean ±
standard deviation for individual determinations is given (n=3).
b Process time is the sum of reactor setup and the
actual fermentation
c Space time yield (STY) calculated according to
Equation 1.
d Chemostat cultivations in which the cultivation
period was limited to the phase before population collapse.
If long-term stability is only possible through reduced productivity,
the question of process efficiency arises. In order to compare fed-batch
and continuous production, we used the space-time-yield (STY; Equation
1) as the evaluation criterion.