Conclusion
In summary, in the current study we demonstrate for the first time an
amelioration of CIA in mice with established arthritis using a
treatment protocol. We show herein a powerful anti-inflammatory
potential of IVIG in attenuating the pathogenesis in CIA in mice .The
beneficial effect was presented by reducing the clinical score,
reducing the titers of anti-collagen type II antibodies and declining
the concentrations of circulating cytokine . Our study may pave the way
for clinicians to reconsider the use of IVIG, as a safe and beneficial
optional treatment in a subgroup of patients with rheumatoid arthritis.