Cell-cell contacts in COVID-MDR, DRESS and MDR are comparable to HC skin
We investigated the cellular contacts amount the cell-types classified in this dataset and compared them to HC samples (Figure 3E). Overall, the patterns of interaction between the indications were very similar. Despite the large differences in interaction counts, we did not observe interactions that were absent in any of the indications while present in another. We also applied our previously published neighborhood algorithm and could not detect recurrent significant changes (data not shown). We conclude that the overall cellular interactions in drug rashes stay intact given that larger amounts of immune cells are present.