Figure 3. Highly activated Mo/Mac clusters in COVID-MDR and
interactionanalyses.
A, Boxplots depicting the fraction of the indicated
CD8+ T cell clusters (upper graph) and
CD4+ T cell clusters (lower graph) among total cells
in the different conditions (COVID-MDR, DRESS, MDR, HC). B,Heatmap of z-scored average expression for each marker of the clustered
CD8+ T cells (left 4 columns) and
CD4+ T cells clustered (right 4 columns). C,Heatmap of z-scored average marker expression of Mo/Mac clustered cells.D, Boxplots represent the fraction of the 4 Mo/Mac clusters
among total cells in the different conditions (COVID-MDR, DRESS, MDR,
HC). E, Circular string graph showing interactions between the
main identified cell types in COVID-MDR, DRESS, MDR and HC (pooled per
indication). We excluded Keratinocytes from the plot and also excluded
one MDR sample which contained very high numbers of Neutrophils. The
cell-types are individually colored and labelled on the outside of the
plot. The number of interactions is also given on the outside of the
plot. Interactions are depicted ingoing and outgoing for each cell-type.