5. Conclusion
A systematic review of 5 RCTs evaluating the efficacy of VDZ in patients with active IBD did not identify a clear correlation between VDZ treatment and the development of arthralgias. At the same time, each study identified a trend toward increased arthralgias in those receiving VDZ compared with placebo. Clinicians should be aware of the presence of a possible link because of the significant morbidity associated with joint pains. Additional studies are needed stratifying patients into more homogenous subsets in order to evaluate whether those at risk of developing new or worsening arthralgias with VDZ treatment can be identified.