5. Conclusion
A systematic review of 5 RCTs evaluating the efficacy of VDZ in patients
with active IBD did not identify a clear correlation between VDZ
treatment and the development of arthralgias. At the same time, each
study identified a trend toward increased arthralgias in those receiving
VDZ compared with placebo. Clinicians should be aware of the presence of
a possible link because of the significant morbidity associated with
joint pains. Additional studies are needed stratifying patients into
more homogenous subsets in order to evaluate whether those at risk of
developing new or worsening arthralgias with VDZ treatment can be
identified.