BMI,
body mass index; pre-BD FEV1, pre-bronchodilator forced expiratory
volume in 1 s; pre-BD FVC, pre-bronchodilator forced vital capacity;
post-BD FEV1, post-bronchodilator forced expiratory volume in 1 s;
post-BD FVC, post-bronchodilator forced vital capacity; PC20,
methacholine provocative concentration causing a 20% drop in FEV1; CRP,
C-reactive protein.
Low folliculin group: patients with log transformed folliculin level
< 4.80.
High folliculin group: patients with log transformed folliculin level ≥
4.80.
a) The combination of current smokers and ex-smokers.
Each percentage is calculated after excluding patients with unknown
smoking status.
Acute exacerbation, previous 1 year: patients who had an acute
exacerbation at least once during the previous 1 year at the time of
enrollment.
Acute exacerbation (/1 year): the average number of acute exacerbations
that occurred during the first 3 years after enrollment.
P values are based on thet -test and Wilcoxon test for continuous variables and the
chi-square test for categorical variables. P values less than
0.05 are in bold.
*Statistical significance defined as P < 0.05.