BMI, body mass index; pre-BD FEV1, pre-bronchodilator forced expiratory volume in 1 s; pre-BD FVC, pre-bronchodilator forced vital capacity; post-BD FEV1, post-bronchodilator forced expiratory volume in 1 s; post-BD FVC, post-bronchodilator forced vital capacity; PC20, methacholine provocative concentration causing a 20% drop in FEV1; CRP, C-reactive protein.
Low folliculin group: patients with log transformed folliculin level < 4.80.
High folliculin group: patients with log transformed folliculin level ≥ 4.80.
a) The combination of current smokers and ex-smokers. Each percentage is calculated after excluding patients with unknown smoking status.
Acute exacerbation, previous 1 year: patients who had an acute exacerbation at least once during the previous 1 year at the time of enrollment.
Acute exacerbation (/1 year): the average number of acute exacerbations that occurred during the first 3 years after enrollment.
P values are based on thet -test and Wilcoxon test for continuous variables and the chi-square test for categorical variables. P values less than 0.05 are in bold.
*Statistical significance defined as P < 0.05.