Blood eosinophil numbers are of limited use to guide biologics: asthma is an airway disease!
Manali Mukherjee and Parameswaran Nair
There is no dispute that eosinophils are associated with asthma, and that their numbers in circulation may increase with asthma symptoms and severity. There is also no dispute that there are number of processes, in addition to IL-5, that may contribute to the recruitment of these cells out of the bone marrow into target organs.