Conclusions
In
this study, we not only provide convincing evidence that thrombin plays
a crucial role in NSCLC, but also
an
explanation as to why intravascular coagulation with generation of
thrombosis has been observed in most patients with solid tumors. We
conclude that thrombin plays an important role in PAR-1-mediated
NSCLC
invasion and metastasis through RhoA and NF-κB signaling cascades via
promoting the expression of MMP9 and IL6. We
conclude
that the highly specific, potent, thrombin
inhibitor
DTIP inhibit tumor spontaneous seeding of the tumor systemically into
the vital organs, tumor metastasis in NSCLC. We suggest treatment with
DTIP should start immediately after diagnosis (before extensive tumor
development) and in conjunction with chemotherapy.