AUC = area under the plasma concentration versus time curve, from time
zero to the last measurable concentration at t = 6 hr;
Cmax = maximum measured plasma concentration over the
time span specified;
Tmax = time of maximum measured plasma concentration;
t1/2 = time required for the concentration of the drug to halve
* for n=4 patients only
Table 3: Treatment emergent adverse events affecting one or
more participants (n=25) during the MAD Stage II of the pilot trial.