2.2 | Oro-buccal (inside of the cheek) Dosing
Medlab Clinical developed the formulation of the cannabis-based medicine (NanaBisTM). Whereas the manufacturer of NanaBisTM was PCI Pharma Services in Melbourne, Australia a GMP accredited facility. PCI Pharma also conducted the filling of the vials containing the drug substance, labelling and packaging and quality assurance release.
The Δ9-THC and CBD formulation of the cannabis-based medicine is a water-soluble submicron particle solution that also contains glycerol, peppermint oil flavor and a non-ionic oil-in-water solubilizer and emulsifying agent that is administered to the oro-buccal mucosa through a sealed pump action device that produced a fine mist spray. One actuation of the pump in this study administered 1.25 mg Δ9-THC and 1.25 mg CBD in a 150 µL volume.