2.2 | Oro-buccal (inside of the cheek) Dosing
Medlab Clinical developed the formulation of the cannabis-based medicine
(NanaBisTM). Whereas the manufacturer of
NanaBisTM was PCI Pharma Services in Melbourne,
Australia a GMP accredited facility. PCI Pharma also conducted the
filling of the vials containing the drug substance, labelling and
packaging and quality assurance release.
The Δ9-THC and CBD formulation of the cannabis-based medicine is a
water-soluble submicron particle solution that also contains glycerol,
peppermint oil flavor and a non-ionic oil-in-water solubilizer and
emulsifying agent that is administered to the oro-buccal mucosa through
a sealed pump action device that produced a fine mist spray. One
actuation of the pump in this study administered 1.25 mg Δ9-THC and 1.25
mg CBD in a 150 µL volume.