Macrolide antibiotic exposure in the first trimester of
pregnancy and risk of congenital anomaly: A European case-control study
Aminkeng Zawuo Leke1; Helen Dolk1;
Maria Loane1; Karen Casson1; Vera
Nelen2; Ingeborg Barišić3; Ester
Garne4; Anke Rissman5; Mary
O’Mahony6; Amanda J Neville7; Anna
Pierini8; Jorieke E.H. Bergman9;
Kari Klungsøyr10; Anna
Materna-Kiryluk11; Anna Latos
Bielenska12; Clara Cavero
Carbonell13; Marie-Claude Addor14;
David Tucker15
- Centre for Maternal, Fetal and Infant Research, Institute for Nursing
and Health Research, Ulster University-UK
- Provinciaal Instituut voor Hygiëne, Antwerp, Belgium
- Children’s Hospital Zagreb, Centre of Excellence for Reproductive and
Regenerative Medicine, Medical School University of Zagreb, Zagreb,
Croatia, Zagreb, Croatia
- Paediatric Department Hospital, Lillebaelt Skovvangen, Kolding,
Denmark
- Malformation Monitoring Centre Saxony-Anhalt, Medical Faculty
Otto-von-Guericke University Magdeburg, Germany
- Medicine Department of Public Health, St Finbarr’s Hospital Douglas
Road, Cork, Ireland
- IMER Registry (Emila Romagna Registry of Birth Defects), Center for
Clinical and Epidemiological Research, University of Ferrara - Azienda
Ospedaliero - Universitaria di Ferrara, Corso della Giovecca, Ferrara,
Italy
- Tuscany Registry of Congenital Defects, CNR Institute of Clinical
Physiology/Fondazione Toscana Gabriele Monasterio, Pisa, Italy
- Department of Medical Genetics, University of Groningen, University
Medical Center Groningen, Groningen, The Netherlands
- Medical Birth Registry of Norway, Kalfarveien, Bergen, Norway
- Polish Registry of Congenital Malformations, Department of
Medical Genetics, Poznan University of Medical Sciences, Poznan,
Poland
- Poznan University of Medical Sciences, Department of Medical Genetics.
8 Rokietnicka Street, 60-806 Poznan, Poland.
- Rare Diseases Research Unit, Foundation for the Promotion of Health
and Biomedical Research in the Valencian Region, Valencia, Spain.
- Registre Vaudois des Malformations EUROCAT Department of
Woman-Mother-Child, Maternité, Lausanne, Switzerland
- Congenital Anomaly Register & Information Service, Level 3 West Wing,
Singleton Hospital, Sketty Lane, Swansea, United Kingdom
Corresponding Author: Aminkeng Zawuo Leke
Centre for Maternal, Fetal and Infant Research, Institute for Nursing
and Health Research,
Ulster University, Shore Road. Newtownabbey, Co. Antrim
BT37 0QB, Northern Ireland United Kingdom
Email:
az.leke@ulster.ac.uk; Tel: +4407568214655
Running title: Macrolides use in pregnancy and risk of
congenital anomalies
Tweetable abstract: Macrolide antibiotics, including
azithromycin considered for COVID-19 treatment, are associated with
increased risk of birth defects.
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