Figure 4: Correlation of (A) miR-122 (fM) vs ALT (IU/L), (B) K18 (U/L) vs ALT (IU/L) and (C) miR-122 (fM) vs K18 (U/L). Patient samples (healthy volunteers n=28; active TB n=44; latent TB n=142; NTM infection n=39; HIV-TB coinfection n=241). Statistical analysis of the significance of the correlation calculated using Spearman’s rank correlation coefficient (miR-122 vs ALT: n=251, Spearman rank r = 0.52, 95% CI 0.42-0.61, P<0.0001) (K18 vs ALT: n=491, Spearman rank r = 0.42, 95% CI 0.34-0.49, P<0.0001) (miR-122 vs K18: n=252, Spearman rank r = 0.32, 95% CI 0.20-0.43, P<0.0001).