Increased M1 macrophage at onset and M2 macrophage at peak of EAE
The percentage of macrophages in the spleen increased at the onset and decreased at the peak phase(P<0.0001). At the recovery stage, the percentage of macrophages decreased continuously(P<0.001). The percentage of M1 macrophages increased at the EAE onset(P<0.0001), then decreased at the peak and recover(P<0.01). Conversely, the percentage of M2 macrophages didn’t increase at the onset(P>0.05) and increased at the peak of EAE(P<0.0001) and decreased a little at recover stage(P<0.05), but still higher than normal(Figure 1b).