Blockade of the NF-κb pathway to treat and prevent EAE
The EAE mice were divided into three groups: 1) EAE control
group(treated with PBS), 2) prevention group(treated with BAY-11-7082 on
day 2, 5, 8, 11, 14, and 17p.i., 20mg/kg/i.p), and 3) treatment
group(treated with BAY-11-7082 on days 10, 13, and 16 p.i, 20mg/kg/i.p).
The weight and clinical score were recorded every day to observe the
changes in the EAE symptoms. Experiments were replicated three
times(n=10).