Lay summary
Intrahepatic cholestasis includes primary biliary cholangitis and primary sclerosing cholangitis. It can cause fibrosis, cirrhosis and eventually liver failure. Effective drugs for PBC and PSC are still limited and new treatment strategies are urgently needed. This study defines tectorigenin, an isoflavone, have the potential to alleviate cholestatic liver disease, which is achieved mainly by relieving liver inflammation and promoting the secretion of bile in hepatocyte.