SNV annotations
Associated variants from the GWAS and GRS analysis were annotated using
the Ensembl Variant Effect Predictor to determine their potential impact
on gene transcription and translation (e.g., transcript expression,
splicing, protein sequence) as well as reported associations with traits
and diseases.(33) Non-coding variants were assessed for potential
regulatory effects (i.e. expression quantitative trait loci) using
RegulomeDB and Genotype-Tissue Expression (GTEx) databases.(34,35)