Genome-wide association study of recurrent wheeze between age 2-5 years. a) Manhattan plot showing SNVs on chromosome 17q12 - 21 associated with recurrent wheeze in the CHILD Study Cohort (p < 5e-8). Y-axis depicts the -log10 transformed p-value and x-axis shows chromosomal positions. Suggestive significance (p=5e-5) and genome-wide significance (p=5e-8) are respectively marked as blue and red horizontal lines, respectively. b) Locus-zoom plot showing the specific region on chromosome 17q12 - 21 associated with recurrent wheeze. Red circles indicate that the SNVs are in strong LD, and numbers within each circle indicate that they are likely to be regulatory. These SNVs span 5 well-known asthma genes: GRB7 ,IKZF3 , ZPBP2 , GSDMB , and ORMLD3 .