3.2. Virus removability of total flow-through integrated
polishing process
In the end-to-end continuous process for mAb purification, virus removal
is expected for the Protein A capture, low pH virus inactivation, two
column chromatography and virus filter steps, with the most robust virus
removability at the virus filtration step. Here, viral clearance testes
were carried out for specific segments of the total flow-through
integrated polishing process.