Metabolic and macroscopic evaluation during ESHP
The arterial pH was measured during the seven hours of reperfusion. With
the aggressive management of sodium bicarbonate and CO2,
pH remained relatively stable during this time period (Fig. 4a). As seen
in Fig. 4b, lactate concentration increased continuously during SAM and
PAM. Lactate concentration (in mmol/L) was 1.15 ± 0.49, 2.77 ± 0.18 and
2.90 ± 0.41 at SAM1, PAM and SAM2 respectively. Arterial and venous
lactate concentration measurements were used to calculate the lactate
extraction (Δlactate) at the different time points. The Δlactate (in
mmol/L) between the venous and arterial perfusate samples was -0.01 ±
0.1, -0.06 ± 0.17, -0.12 ± 0.21 at SAM1, PAM and SAM2 respectively (Fig.
4c). As seen in table 2, myocardial weight increased during the
experiment.