BTT with VV-ECMO Non-BTT p1
N 21 276
Preoperative characteristics
Age, years 30.5 (23-34.8; 19-56) 49 (30.2-57.8; 19-71) <0.001
Male gender 13 (61.9) 152 (55.1) 0.544
Body mass index, kg/m2 20.2 (19-23; 17.7-27.9) 22.1 (19.5-25.5; 14.7-58.1) 0.062
Hemoglobin, g/L 84 (78-91; 71-103) 137 (121-149; 59-196) <0.001
Hemoglobin <90 g/L 16 (76.2) 11 (4.0) <0.001
Platelet count, x109/L 153 (84-257; 37-550) 273 (221-357; 52-659) <0.001
Platelet count <150 x109/L 11 (52.4) 19 (6.9) <0.001
aPTT, seconds 49.5 (43.8-66.2; 34.5-97.1) 32 (29-34.5; 17.7-108.5) <0.001
INR 1.2 (1.1-1.4; 0.9-1.7) 1.0 (0.9-1.1; 0.8-2.5) <0.001
Creatinine, µmol/L 58 (33-70; 19-94) 59 (50-72.5; 24-142) 0.237
FVC, L 1.62 (1.36-2.18; 0.73-3.23) 1.88 (1.43-2.37; 0.39-4.98) 0.316
FEV1, L 0.97 (0.62-1.36; 0.41-2.30) 0.73 (0.55-0.92; 0.20-3.61) 0.037
Renal replacement therapy 1 (4.8) 1 (0.4) 0.100
Mechanical ventilation 8 (38.1) 0
Diagnosis
Cystic fibrosis 19 (90.5) 108 (39.1) <0.001
COPD/emphysema/bronchiectasis 0 99 (35.9)
α1-antitrypsin deficiency 1 (4.8) 34 (12.3) 0.300
Pulmonary fibrosis/ILD 1 (4.8) 27 (9.8) 0.448
Lymphangioleiomyomatosis 0 5 (1,8)
Pulmonary hypertension 0 3 (1.1)
Preoperative VV-ECMO duration, d 8 (6.5-16; 1-53)
Intraoperative characteristics
Bilateral lung transplant 21 (100) 268 (97.1)
Cardiopulmonary bypass 6 (28.6) 94 (34.1) 0.608
ECMO 15(71.4) 15 (5.4) <0.001
Transfusion (24h)
Red blood cells, units 13.5 (8.2-41.8; 5-53) 3 (1-3, 0-71) <0.001
Platelets, pools 3.5 (1.2-8.5; 0-21) 1 (0-2; 0-18) <0.001
Fresh frozen plasma, units 6 (2.5-11; 0-37) 2 (0-4; 0-32) <0.001
Cryoprecipitate, units 8 (38.1) (median 3.5 units) 45 (16.3) (median 2 units) 0.022