First Author COG Study COG Study Reference Findings Outcome/Follow-up Study Outcome/Follow-up Study
Zerr ACCL1034 ACCL1034 59 Chlorhexidine gluconate (CHG) cloth bathing (n=88) vs placebo (n=87) to reduce central venous catheter associated blood stream infection (CLABSI). Cumulative incidence of CLABSI was similar for CHG (35%) vs control (24%, p=0.09). CHG was associated with a higher risk of cutaneous Staph isolates resistant to CHG. CHG baths not recommended for prevention of CLABSI CHG baths not recommended for prevention of CLABSI
Alexander ACCL0934 ACCL0934 33 Randomized pts with leukemia (AML or relapsed ALL, n=200) or HCT pts (n=424) to levofloxacin prophylaxis or none. Acute leukemia patients had less bacteremia if they received levofloxacin (22 vs 43%, p=0.001), but no significant difference in HCT patients (11% vs 17%, p=0.06) Levofloxacin prophylaxis not recommended for prevention of bacteremia in HCT patients. Levofloxacin prophylaxis not recommended for prevention of bacteremia in HCT patients.
Analysis ongoing Analysis ongoing ACCL1633 Randomized trial of lactobacillus vs placebo to decrease incidence of GI acute GVHD was found to be futile at the first interim analysis. Correlative studies of microbiome, biomarkers, and transplant outcomes underway.
Dvorak Dvorak ACCL1131 34 Patients undergoing allogeneic HCT were randomized to caspofungin (n=144) or triazole (fluconazole n=100, voriconazole n=46). Planned analysis found rates of IFD (1.4%) too low to detect differences between arms and study was closed early.
Otto Otto ACCL1131 – Ancillary study 35 Weekly beta-D-glucan levels from 51 patients were correlated with IFD. None of the 25 patients with at least 1 positive test developed IFI (false positive rate 100%). Serial monitoring of BDG for fungal surveillance not recommended.