Zerr |
ACCL1034 |
ACCL1034 |
59 |
Chlorhexidine
gluconate (CHG) cloth bathing (n=88) vs placebo (n=87) to reduce central
venous catheter associated blood stream infection (CLABSI). Cumulative
incidence of CLABSI was similar for CHG (35%) vs control (24%,
p=0.09). CHG was associated with a higher risk of cutaneous Staph
isolates resistant to CHG. |
CHG baths not recommended for prevention of
CLABSI |
CHG baths not recommended for prevention of
CLABSI |
Alexander |
ACCL0934 |
ACCL0934 |
33 |
Randomized pts
with leukemia (AML or relapsed ALL, n=200) or HCT pts (n=424) to
levofloxacin prophylaxis or none. Acute leukemia patients had less
bacteremia if they received levofloxacin (22 vs 43%, p=0.001), but no
significant difference in HCT patients (11% vs 17%, p=0.06) |
Levofloxacin prophylaxis not recommended for prevention of bacteremia in
HCT patients. |
Levofloxacin prophylaxis not recommended for prevention
of bacteremia in HCT patients. |
Analysis ongoing |
Analysis ongoing |
ACCL1633 |
|
Randomized trial of
lactobacillus vs placebo to decrease incidence of GI acute GVHD was
found to be futile at the first interim analysis. |
Correlative studies
of microbiome, biomarkers, and transplant outcomes
underway. |
|
Dvorak |
Dvorak |
ACCL1131 |
34 |
Patients undergoing
allogeneic HCT were randomized to caspofungin (n=144) or triazole
(fluconazole n=100, voriconazole n=46). Planned analysis found rates of
IFD (1.4%) too low to detect differences between arms and study was
closed early. |
|
|
Otto |
Otto |
ACCL1131 – Ancillary study |
35 |
Weekly beta-D-glucan levels from 51 patients were correlated with IFD.
None of the 25 patients with at least 1 positive test developed IFI
(false positive rate 100%). |
Serial monitoring of BDG for fungal
surveillance not recommended. |
|